Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF-MazE
Location 613558..614183 Replicon chromosome
Accession NZ_CP119416
Organism Agrobacterium fabrum strain A8196

Toxin (Protein)


Gene name mazF Uniprot ID Q7D0B1
Locus tag P0M24_RS03115 Protein ID WP_006311244.1
Coordinates 613824..614183 (+) Length 120 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q7D0B2
Locus tag P0M24_RS03110 Protein ID WP_010971270.1
Coordinates 613558..613824 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P0M24_RS03080 (P0M24_03080) 608732..609067 - 336 WP_010971265.1 type II toxin-antitoxin system YafQ family toxin -
P0M24_RS03085 (P0M24_03085) 609064..609339 - 276 WP_010971266.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
P0M24_RS03090 (P0M24_03090) 609447..610055 + 609 WP_010971267.1 class I SAM-dependent methyltransferase -
P0M24_RS03095 (P0M24_03095) 610231..612816 + 2586 WP_035256421.1 heavy metal translocating P-type ATPase -
P0M24_RS03100 (P0M24_03100) 612813..613235 + 423 WP_006311241.1 Cu(I)-responsive transcriptional regulator -
P0M24_RS03105 (P0M24_03105) 613288..613488 + 201 WP_006311242.1 heavy-metal-associated domain-containing protein -
P0M24_RS03110 (P0M24_03110) 613558..613824 + 267 WP_010971270.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
P0M24_RS03115 (P0M24_03115) 613824..614183 + 360 WP_006311244.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
P0M24_RS03120 (P0M24_03120) 614191..614439 - 249 WP_006311245.1 hypothetical protein -
P0M24_RS03125 (P0M24_03125) 614618..616006 + 1389 WP_169539085.1 MFS transporter -
P0M24_RS03130 (P0M24_03130) 616085..616258 - 174 WP_010971273.1 hypothetical protein -
P0M24_RS03135 (P0M24_03135) 616327..618045 - 1719 WP_035256424.1 glycoside hydrolase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-111)

Antitoxin

SpoVT-AbrB domain

(14-52)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 12857.04 Da        Isoelectric Point: 8.2782

>T274135 WP_006311244.1 NZ_CP119416:613824-614183 [Agrobacterium fabrum]
MVRNQIPKRGDVYLVDLNPVVGSEIKDEHRCVVITPREINAVGLCLVVPVTTGGMFTRKAGLAVNISGHKTTGVALCNQV
RSMDIVARVAQKKAKYIETLDDATIDEIAGRVISMIDPA

Download         Length: 360 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9423.02 Da        Isoelectric Point: 5.1106

>AT274135 WP_010971270.1 NZ_CP119416:613558-613824 [Agrobacterium fabrum]
MTVTTKIRRQGGAAVMTIPPALLKMLGLEIGEQLTLEVDNGALVASPVRLEKKRFTLAELLDGAEEVAALNARERAWDTA
PPVGKEAL

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q7D0B1

Antitoxin

Source ID Structure
AlphaFold DB Q7D0B2

References