Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 608732..609339 Replicon chromosome
Accession NZ_CP119416
Organism Agrobacterium fabrum strain A8196

Toxin (Protein)


Gene name relE Uniprot ID Q7D0B7
Locus tag P0M24_RS03080 Protein ID WP_010971265.1
Coordinates 608732..609067 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A9CJP8
Locus tag P0M24_RS03085 Protein ID WP_010971266.1
Coordinates 609064..609339 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P0M24_RS03065 (P0M24_03065) 604837..607032 - 2196 WP_035256415.1 transglycosylase domain-containing protein -
P0M24_RS03070 (P0M24_03070) 607289..607768 + 480 WP_010971263.1 YcgN family cysteine cluster protein -
P0M24_RS03075 (P0M24_03075) 607880..608704 + 825 WP_010971264.1 class D beta-lactamase -
P0M24_RS03080 (P0M24_03080) 608732..609067 - 336 WP_010971265.1 type II toxin-antitoxin system YafQ family toxin Toxin
P0M24_RS03085 (P0M24_03085) 609064..609339 - 276 WP_010971266.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
P0M24_RS03090 (P0M24_03090) 609447..610055 + 609 WP_010971267.1 class I SAM-dependent methyltransferase -
P0M24_RS03095 (P0M24_03095) 610231..612816 + 2586 WP_035256421.1 heavy metal translocating P-type ATPase -
P0M24_RS03100 (P0M24_03100) 612813..613235 + 423 WP_006311241.1 Cu(I)-responsive transcriptional regulator -
P0M24_RS03105 (P0M24_03105) 613288..613488 + 201 WP_006311242.1 heavy-metal-associated domain-containing protein -
P0M24_RS03110 (P0M24_03110) 613558..613824 + 267 WP_010971270.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
P0M24_RS03115 (P0M24_03115) 613824..614183 + 360 WP_006311244.1 type II toxin-antitoxin system PemK/MazF family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(23-110)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-67)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12991.86 Da        Isoelectric Point: 10.0059

>T274134 WP_010971265.1 NZ_CP119416:c609067-608732 [Agrobacterium fabrum]
VTNKKDHGKDAALKRATLPRRSDFTKQFIKDWQRLNNSGRYDMVRLKEIMLLLIANGAPLPTQFRDHELTGDWRDHRECH
VGGDFLLIYTVDEKQNLLIFTRAGTHAELFR

Download         Length: 336 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9918.40 Da        Isoelectric Point: 6.3350

>AT274134 WP_010971266.1 NZ_CP119416:c609339-609064 [Agrobacterium fabrum]
MTANAYVRARIDQTLKDDATAVLDRLGLTVSDVMRMMLTRIAREKALPIELTQPNAETLAAIEEARAIAAAGRNRFGTSE
ALFEALDAGKR

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q7D0B7

Antitoxin

Source ID Structure
AlphaFold DB A9CJP8

References