Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4604298..4605108 Replicon chromosome
Accession NZ_CP119408
Organism Klebsiella pneumoniae strain NW202109

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag P0M34_RS22605 Protein ID WP_048299784.1
Coordinates 4604298..4604831 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag P0M34_RS22610 Protein ID WP_002887278.1
Coordinates 4604842..4605108 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P0M34_RS22600 (4603129) 4603129..4604250 + 1122 WP_004214138.1 cupin domain-containing protein -
P0M34_RS22605 (4604298) 4604298..4604831 - 534 WP_048299784.1 type II toxin-antitoxin system toxin KacT Toxin
P0M34_RS22610 (4604842) 4604842..4605108 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
P0M34_RS22615 (4605211) 4605211..4606644 - 1434 WP_040210879.1 Cu(+)/Ag(+) sensor histidine kinase -
P0M34_RS22620 (4606634) 4606634..4607317 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
P0M34_RS22625 (4607489) 4607489..4608874 + 1386 WP_040089708.1 efflux transporter outer membrane subunit -
P0M34_RS22630 (4608892) 4608892..4609236 + 345 WP_023287080.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19826.65 Da        Isoelectric Point: 5.2614

>T274122 WP_048299784.1 NZ_CP119408:c4604831-4604298 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGYDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT274122 WP_002887278.1 NZ_CP119408:c4605108-4604842 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References