Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2627081..2628669 Replicon chromosome
Accession NZ_CP119408
Organism Klebsiella pneumoniae strain NW202109

Toxin (Protein)


Gene name hipA Uniprot ID A0A9J6RYF8
Locus tag P0M34_RS12965 Protein ID WP_004892016.1
Coordinates 2627081..2628403 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag P0M34_RS12970 Protein ID WP_002904790.1
Coordinates 2628403..2628669 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P0M34_RS12950 (2622137) 2622137..2624638 + 2502 WP_058330999.1 fimbria/pilus outer membrane usher protein -
P0M34_RS12955 (2624626) 2624626..2625630 + 1005 WP_202021197.1 fimbrial protein -
P0M34_RS12960 (2625772) 2625772..2627064 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
P0M34_RS12965 (2627081) 2627081..2628403 - 1323 WP_004892016.1 type II toxin-antitoxin system HipA family toxin Toxin
P0M34_RS12970 (2628403) 2628403..2628669 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
P0M34_RS12975 (2629055) 2629055..2629381 - 327 WP_002904788.1 hydroxyisourate hydrolase -
P0M34_RS12980 (2629378) 2629378..2629878 - 501 WP_032412207.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
P0M34_RS12985 (2629856) 2629856..2631235 - 1380 WP_202021199.1 nucleobase:cation symporter-2 family protein -
P0M34_RS12990 (2631581) 2631581..2632735 + 1155 WP_020804972.1 FAD-dependent urate hydroxylase HpxO -
P0M34_RS12995 (2632716) 2632716..2633639 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49141.44 Da        Isoelectric Point: 7.5357

>T274120 WP_004892016.1 NZ_CP119408:c2628403-2627081 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT274120 WP_002904790.1 NZ_CP119408:c2628669-2628403 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References