Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 807084..807741 Replicon chromosome
Accession NZ_CP119408
Organism Klebsiella pneumoniae strain NW202109

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag P0M34_RS04000 Protein ID WP_002916310.1
Coordinates 807331..807741 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag P0M34_RS03995 Protein ID WP_002916312.1
Coordinates 807084..807350 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P0M34_RS03970 (802292) 802292..803725 - 1434 WP_085205679.1 6-phospho-beta-glucosidase -
P0M34_RS03975 (803844) 803844..804572 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
P0M34_RS03980 (804622) 804622..804933 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
P0M34_RS03985 (805097) 805097..805756 + 660 WP_004174454.1 hemolysin III family protein -
P0M34_RS03990 (805855) 805855..806838 - 984 WP_023286864.1 tRNA-modifying protein YgfZ -
P0M34_RS03995 (807084) 807084..807350 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
P0M34_RS04000 (807331) 807331..807741 + 411 WP_002916310.1 protein YgfX Toxin
P0M34_RS04005 (807748) 807748..808269 - 522 WP_004144730.1 flavodoxin FldB -
P0M34_RS04010 (808370) 808370..809266 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
P0M34_RS04015 (809289) 809289..810002 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
P0M34_RS04020 (810008) 810008..811741 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T274115 WP_002916310.1 NZ_CP119408:807331-807741 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT274115 WP_002916312.1 NZ_CP119408:807084-807350 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References