Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 20073..20608 Replicon plasmid pMRE162 UK
Accession NZ_CP119405
Organism Escherichia coli strain MRE162 substr. UK

Toxin (Protein)


Gene name relE Uniprot ID A0A0K4CX11
Locus tag PX811_RS22950 Protein ID WP_000222771.1
Coordinates 20321..20608 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID T1PXV2
Locus tag PX811_RS22945 Protein ID WP_001139206.1
Coordinates 20073..20324 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PX811_RS22925 (PX811_004583) 15153..15874 + 722 Protein_21 helix-turn-helix domain-containing protein -
PX811_RS22930 (PX811_004584) 15913..16161 - 249 WP_000747846.1 hypothetical protein -
PX811_RS22935 (PX811_004585) 16158..16598 - 441 WP_023352064.1 hypothetical protein -
PX811_RS22940 (PX811_004586) 16632..19490 - 2859 Protein_24 hypothetical protein -
PX811_RS22945 (PX811_004587) 20073..20324 + 252 WP_001139206.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PX811_RS22950 (PX811_004588) 20321..20608 + 288 WP_000222771.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PX811_RS22955 (PX811_004589) 20976..21089 - 114 Protein_27 alkaline phosphatase -
PX811_RS22960 (PX811_004590) 21088..21293 + 206 Protein_28 hypothetical protein -
PX811_RS22965 (PX811_004591) 21468..24965 - 3498 WP_001038839.1 autotransporter outer membrane beta-barrel domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..76855 76855


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11116.17 Da        Isoelectric Point: 10.5833

>T274113 WP_000222771.1 NZ_CP119405:20321-20608 [Escherichia coli]
MTYTVKFRDDALKEWLRLDKTIQQQFAKKLKKCSENPHIASAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSNVYHLASERMK

Download         Length: 288 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9171.39 Da        Isoelectric Point: 4.0927

>AT274113 WP_001139206.1 NZ_CP119405:20073-20324 [Escherichia coli]
MPSIILSDTSASVSELKKNPMATVSAGEGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSSQPLHDVDLD
SYL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K4CX11

Antitoxin

Source ID Structure
AlphaFold DB T1PXV2

References