Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 3977402..3977978 Replicon chromosome
Accession NZ_CP119404
Organism Escherichia coli strain MRE162 substr. UK

Toxin (Protein)


Gene name shpA Uniprot ID D3GXZ2
Locus tag PX811_RS19380 Protein ID WP_001297643.1
Coordinates 3977691..3977978 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A829G8Z0
Locus tag PX811_RS19375 Protein ID WP_000063156.1
Coordinates 3977402..3977704 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PX811_RS19360 (3973998) 3973998..3976148 + 2151 WP_001295524.1 pyruvate/proton symporter BtsT -
PX811_RS19365 (3976198) 3976198..3976401 + 204 WP_000467859.1 YbdD/YjiX family protein -
PX811_RS19370 (3976412) 3976412..3977368 + 957 WP_001297640.1 GTPase -
PX811_RS19375 (3977402) 3977402..3977704 - 303 WP_000063156.1 BrnA antitoxin family protein Antitoxin
PX811_RS19380 (3977691) 3977691..3977978 - 288 WP_001297643.1 BrnT family toxin Toxin
PX811_RS19385 (3978177) 3978177..3978874 - 698 Protein_3787 IS1 family transposase -
PX811_RS19390 (3978931) 3978931..3979026 + 96 Protein_3788 dienelactone hydrolase family protein -
PX811_RS19395 (3979172) 3979172..3980404 + 1233 WP_024186283.1 multidrug efflux MFS transporter MdtM -
PX811_RS19400 (3980445) 3980445..3981725 + 1281 WP_001037400.1 DUF445 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11295.77 Da        Isoelectric Point: 6.8821

>T274109 WP_001297643.1 NZ_CP119404:c3977978-3977691 [Escherichia coli]
MPMEFEWDENKAKSNRVKHGIRFEDAVLLFDDPQHLSQQERIENGEYRWQTIGLVYGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11521.99 Da        Isoelectric Point: 9.4646

>AT274109 WP_000063156.1 NZ_CP119404:c3977704-3977402 [Escherichia coli]
MSMVKHKRGTSSTLDVQHEAELKALANKSDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GEV9

Antitoxin

Source ID Structure
AlphaFold DB A0A829G8Z0

References