Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3440845..3441463 Replicon chromosome
Accession NZ_CP119404
Organism Escherichia coli strain MRE162 substr. UK

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag PX811_RS16785 Protein ID WP_001291435.1
Coordinates 3441245..3441463 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag PX811_RS16780 Protein ID WP_000344800.1
Coordinates 3440845..3441219 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PX811_RS16770 (3435934) 3435934..3437127 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PX811_RS16775 (3437150) 3437150..3440299 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
PX811_RS16780 (3440845) 3440845..3441219 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
PX811_RS16785 (3441245) 3441245..3441463 + 219 WP_001291435.1 HHA domain-containing protein Toxin
PX811_RS16790 (3441635) 3441635..3442186 + 552 WP_000102564.1 maltose O-acetyltransferase -
PX811_RS16795 (3442302) 3442302..3442772 + 471 WP_000136192.1 YlaC family protein -
PX811_RS16800 (3442936) 3442936..3444486 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
PX811_RS16805 (3444528) 3444528..3444881 - 354 WP_000878140.1 DUF1428 domain-containing protein -
PX811_RS16815 (3445260) 3445260..3445571 + 312 WP_000409911.1 MGMT family protein -
PX811_RS16820 (3445602) 3445602..3446174 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T274106 WP_001291435.1 NZ_CP119404:3441245-3441463 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT274106 WP_000344800.1 NZ_CP119404:3440845-3441219 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References