Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2417009..2417647 Replicon chromosome
Accession NZ_CP119404
Organism Escherichia coli strain MRE162 substr. UK

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag PX811_RS11750 Protein ID WP_000813794.1
Coordinates 2417471..2417647 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PX811_RS11745 Protein ID WP_077875187.1
Coordinates 2417009..2417425 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PX811_RS11725 (2412161) 2412161..2413102 - 942 WP_001251313.1 ABC transporter permease -
PX811_RS11730 (2413103) 2413103..2414116 - 1014 WP_000220399.1 ABC transporter ATP-binding protein -
PX811_RS11735 (2414134) 2414134..2415279 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
PX811_RS11740 (2415524) 2415524..2416930 - 1407 WP_000760585.1 PLP-dependent aminotransferase family protein -
PX811_RS11745 (2417009) 2417009..2417425 - 417 WP_077875187.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
PX811_RS11750 (2417471) 2417471..2417647 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
PX811_RS11755 (2417869) 2417869..2418099 + 231 WP_000494244.1 YncJ family protein -
PX811_RS11760 (2418191) 2418191..2420152 - 1962 WP_001301045.1 23S rRNA 5-hydroxycytidine C2501 synthase -
PX811_RS11765 (2420225) 2420225..2420761 - 537 WP_000429133.1 DNA-binding transcriptional regulator SutR -
PX811_RS11770 (2420853) 2420853..2422028 + 1176 WP_001236251.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2422360..2423334 974


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T274105 WP_000813794.1 NZ_CP119404:c2417647-2417471 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15260.66 Da        Isoelectric Point: 4.7386

>AT274105 WP_077875187.1 NZ_CP119404:c2417425-2417009 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKI
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References