Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 71182..71717 Replicon plasmid pMRE162 FRA
Accession NZ_CP119403
Organism Escherichia coli strain MRE162 substr. FRA

Toxin (Protein)


Gene name relE Uniprot ID A0A0K4CX11
Locus tag PX810_RS23175 Protein ID WP_000222771.1
Coordinates 71182..71469 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID T1PXV2
Locus tag PX810_RS23180 Protein ID WP_001139206.1
Coordinates 71466..71717 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PX810_RS23160 (PX810_004630) 66825..70322 + 3498 WP_001038839.1 autotransporter outer membrane beta-barrel domain-containing protein -
PX810_RS23165 (PX810_004631) 70497..70702 - 206 Protein_76 hypothetical protein -
PX810_RS23170 (PX810_004632) 70701..70814 + 114 Protein_77 alkaline phosphatase -
PX810_RS23175 (PX810_004633) 71182..71469 - 288 WP_000222771.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PX810_RS23180 (PX810_004634) 71466..71717 - 252 WP_001139206.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PX810_RS23185 (PX810_004635) 72300..75158 + 2859 Protein_80 hypothetical protein -
PX810_RS23190 (PX810_004636) 75192..75632 + 441 WP_023352064.1 hypothetical protein -
PX810_RS23195 (PX810_004637) 75629..75877 + 249 WP_000747846.1 hypothetical protein -
PX810_RS23200 (PX810_004638) 75916..76637 - 722 Protein_83 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..76849 76849


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11116.17 Da        Isoelectric Point: 10.5833

>T274094 WP_000222771.1 NZ_CP119403:c71469-71182 [Escherichia coli]
MTYTVKFRDDALKEWLRLDKTIQQQFAKKLKKCSENPHIASAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSNVYHLASERMK

Download         Length: 288 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9171.39 Da        Isoelectric Point: 4.0927

>AT274094 WP_001139206.1 NZ_CP119403:c71717-71466 [Escherichia coli]
MPSIILSDTSASVSELKKNPMATVSAGEGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSSQPLHDVDLD
SYL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K4CX11

Antitoxin

Source ID Structure
AlphaFold DB T1PXV2

References