Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4008317..4009115 Replicon chromosome
Accession NZ_CP119402
Organism Escherichia coli strain MRE162 substr. FRA

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1X1M0U2
Locus tag PX810_RS19550 Protein ID WP_000854919.1
Coordinates 4008317..4008694 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A2G4AEZ5
Locus tag PX810_RS19555 Protein ID WP_001285608.1
Coordinates 4008741..4009115 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PX810_RS19515 (4003530) 4003530..4004636 + 1107 WP_001353974.1 N-acetylneuraminate epimerase -
PX810_RS19520 (4004701) 4004701..4005681 + 981 WP_001295601.1 sialate O-acetylesterase -
PX810_RS19525 (4005689) 4005689..4006339 - 651 WP_001037966.1 HNH endonuclease -
PX810_RS19530 (4006476) 4006476..4006619 + 144 Protein_3816 HNH endonuclease -
PX810_RS19535 (4007387) 4007387..4007530 - 144 Protein_3817 hypothetical protein -
PX810_RS19540 (4007615) 4007615..4007812 - 198 WP_001327226.1 DUF957 domain-containing protein -
PX810_RS19545 (4007832) 4007832..4008320 - 489 WP_000777664.1 DUF5983 family protein -
PX810_RS19550 (4008317) 4008317..4008694 - 378 WP_000854919.1 TA system toxin CbtA family protein Toxin
PX810_RS19555 (4008741) 4008741..4009115 - 375 WP_001285608.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
PX810_RS19560 (4009195) 4009195..4009416 - 222 WP_000692350.1 DUF987 domain-containing protein -
PX810_RS19565 (4009503) 4009503..4009979 - 477 WP_001560293.1 RadC family protein -
PX810_RS19570 (4009994) 4009994..4010473 - 480 WP_000706978.1 antirestriction protein -
PX810_RS19575 (4010739) 4010739..4011557 - 819 WP_001175165.1 DUF932 domain-containing protein -
PX810_RS19580 (4011647) 4011647..4011880 - 234 WP_001278293.1 DUF905 family protein -
PX810_RS19585 (4011886) 4011886..4012563 - 678 WP_001097302.1 hypothetical protein -
PX810_RS19590 (4012711) 4012711..4013391 - 681 WP_001282921.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimE / fimB 3999665..4029216 29551


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14037.97 Da        Isoelectric Point: 7.9086

>T274091 WP_000854919.1 NZ_CP119402:c4008694-4008317 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGTSSQLINSIDILRARRATGLMTRSNYRTVNNITLGKHPEAKQ

Download         Length: 378 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13610.37 Da        Isoelectric Point: 5.5051

>AT274091 WP_001285608.1 NZ_CP119402:c4009115-4008741 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHPDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAPAITS

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X1M0U2

Antitoxin

Source ID Structure
AlphaFold DB A0A2G4AEZ5

References