Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 3972073..3972649 Replicon chromosome
Accession NZ_CP119402
Organism Escherichia coli strain MRE162 substr. FRA

Toxin (Protein)


Gene name shpA Uniprot ID D3GXZ2
Locus tag PX810_RS19350 Protein ID WP_001297643.1
Coordinates 3972362..3972649 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A829G8Z0
Locus tag PX810_RS19345 Protein ID WP_000063156.1
Coordinates 3972073..3972375 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PX810_RS19330 (3968669) 3968669..3970819 + 2151 WP_001295524.1 pyruvate/proton symporter BtsT -
PX810_RS19335 (3970869) 3970869..3971072 + 204 WP_000467859.1 YbdD/YjiX family protein -
PX810_RS19340 (3971083) 3971083..3972039 + 957 WP_001297640.1 GTPase -
PX810_RS19345 (3972073) 3972073..3972375 - 303 WP_000063156.1 BrnA antitoxin family protein Antitoxin
PX810_RS19350 (3972362) 3972362..3972649 - 288 WP_001297643.1 BrnT family toxin Toxin
PX810_RS19355 (3972848) 3972848..3973545 - 698 Protein_3781 IS1 family transposase -
PX810_RS19360 (3973602) 3973602..3973697 + 96 Protein_3782 dienelactone hydrolase family protein -
PX810_RS19365 (3973843) 3973843..3975075 + 1233 WP_024186283.1 multidrug efflux MFS transporter MdtM -
PX810_RS19370 (3975116) 3975116..3976396 + 1281 WP_001037400.1 DUF445 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11295.77 Da        Isoelectric Point: 6.8821

>T274090 WP_001297643.1 NZ_CP119402:c3972649-3972362 [Escherichia coli]
MPMEFEWDENKAKSNRVKHGIRFEDAVLLFDDPQHLSQQERIENGEYRWQTIGLVYGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11521.99 Da        Isoelectric Point: 9.4646

>AT274090 WP_000063156.1 NZ_CP119402:c3972375-3972073 [Escherichia coli]
MSMVKHKRGTSSTLDVQHEAELKALANKSDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GEV9

Antitoxin

Source ID Structure
AlphaFold DB A0A829G8Z0

References