Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3440410..3441028 Replicon chromosome
Accession NZ_CP119400
Organism Escherichia coli strain MRE162 substr. NOR

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag PX809_RS16760 Protein ID WP_001291435.1
Coordinates 3440810..3441028 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag PX809_RS16755 Protein ID WP_000344800.1
Coordinates 3440410..3440784 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PX809_RS16745 (3435499) 3435499..3436692 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PX809_RS16750 (3436715) 3436715..3439864 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
PX809_RS16755 (3440410) 3440410..3440784 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
PX809_RS16760 (3440810) 3440810..3441028 + 219 WP_001291435.1 HHA domain-containing protein Toxin
PX809_RS16765 (3441200) 3441200..3441751 + 552 WP_000102564.1 maltose O-acetyltransferase -
PX809_RS16770 (3441867) 3441867..3442337 + 471 WP_000136192.1 YlaC family protein -
PX809_RS16775 (3442501) 3442501..3444051 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
PX809_RS16780 (3444093) 3444093..3444446 - 354 WP_000878140.1 DUF1428 domain-containing protein -
PX809_RS16790 (3444825) 3444825..3445136 + 312 WP_000409911.1 MGMT family protein -
PX809_RS16795 (3445167) 3445167..3445739 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T274068 WP_001291435.1 NZ_CP119400:3440810-3441028 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT274068 WP_000344800.1 NZ_CP119400:3440410-3440784 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References