Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2416935..2417573 Replicon chromosome
Accession NZ_CP119400
Organism Escherichia coli strain MRE162 substr. NOR

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag PX809_RS11735 Protein ID WP_000813794.1
Coordinates 2417397..2417573 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PX809_RS11730 Protein ID WP_077875187.1
Coordinates 2416935..2417351 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PX809_RS11710 (2412087) 2412087..2413028 - 942 WP_001251313.1 ABC transporter permease -
PX809_RS11715 (2413029) 2413029..2414042 - 1014 WP_000220399.1 ABC transporter ATP-binding protein -
PX809_RS11720 (2414060) 2414060..2415205 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
PX809_RS11725 (2415450) 2415450..2416856 - 1407 WP_000760585.1 PLP-dependent aminotransferase family protein -
PX809_RS11730 (2416935) 2416935..2417351 - 417 WP_077875187.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
PX809_RS11735 (2417397) 2417397..2417573 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
PX809_RS11740 (2417795) 2417795..2418025 + 231 WP_000494244.1 YncJ family protein -
PX809_RS11745 (2418117) 2418117..2420078 - 1962 WP_001301045.1 23S rRNA 5-hydroxycytidine C2501 synthase -
PX809_RS11750 (2420151) 2420151..2420687 - 537 WP_000429133.1 DNA-binding transcriptional regulator SutR -
PX809_RS11755 (2420740) 2420740..2421954 + 1215 WP_071597387.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2422286..2423260 974


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T274067 WP_000813794.1 NZ_CP119400:c2417573-2417397 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15260.66 Da        Isoelectric Point: 4.7386

>AT274067 WP_077875187.1 NZ_CP119400:c2417351-2416935 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKI
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References