274056

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1241305..1242222 Replicon chromosome
Accession NZ_CP119399
Organism Bacillus velezensis strain HBXN2020

Toxin (Protein)


Gene name spoIISA Uniprot ID I2HQ15
Locus tag P0M22_RS06485 Protein ID WP_007407256.1
Coordinates 1241476..1242222 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID I2HQ14
Locus tag P0M22_RS06480 Protein ID WP_003154807.1
Coordinates 1241305..1241475 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P0M22_RS06440 (P0M22_06440) 1236538..1238160 + 1623 WP_032874601.1 pyocin knob domain-containing protein -
P0M22_RS06445 (P0M22_06445) 1238173..1238544 + 372 WP_032874603.1 XkdW family protein -
P0M22_RS06450 (P0M22_06450) 1238549..1238746 + 198 WP_032874605.1 XkdX family protein -
P0M22_RS06455 (P0M22_06455) 1238803..1239564 + 762 WP_032874607.1 hypothetical protein -
P0M22_RS06460 (P0M22_06460) 1239616..1239879 + 264 WP_003154815.1 hemolysin XhlA family protein -
P0M22_RS06465 (P0M22_06465) 1239893..1240156 + 264 WP_003154813.1 phage holin -
P0M22_RS06470 (P0M22_06470) 1240170..1241048 + 879 WP_032874609.1 N-acetylmuramoyl-L-alanine amidase -
P0M22_RS06475 (P0M22_06475) 1241083..1241208 - 126 WP_003154809.1 hypothetical protein -
P0M22_RS06480 (P0M22_06480) 1241305..1241475 - 171 WP_003154807.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
P0M22_RS06485 (P0M22_06485) 1241476..1242222 - 747 WP_007407256.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
P0M22_RS06490 (P0M22_06490) 1242327..1243325 - 999 WP_032874611.1 inorganic phosphate transporter -
P0M22_RS06495 (P0M22_06495) 1243338..1243955 - 618 WP_032874614.1 DUF47 domain-containing protein -
P0M22_RS06500 (P0M22_06500) 1244241..1245557 - 1317 WP_032874616.1 amino acid permease -
P0M22_RS06505 (P0M22_06505) 1245879..1246829 + 951 WP_032874618.1 ring-cleaving dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1197551..1300074 102523


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-239)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29077.57 Da        Isoelectric Point: 4.7755

>T274056 WP_007407256.1 NZ_CP119399:c1242222-1241476 [Bacillus velezensis]
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVLGSMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYAEKMNVTASL
CDYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQNRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6676.74 Da        Isoelectric Point: 10.9273

>AT274056 WP_003154807.1 NZ_CP119399:c1241475-1241305 [Bacillus velezensis]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I2HQ15

Antitoxin

Source ID Structure
AlphaFold DB I2HQ14

References