Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 705650..706235 Replicon chromosome
Accession NZ_CP119393
Organism Enterococcus casseliflavus strain ASE4

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag P0G38_RS03355 Protein ID WP_159160750.1
Coordinates 705650..706015 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag P0G38_RS03360 Protein ID WP_159160751.1
Coordinates 706005..706235 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P0G38_RS03325 (P0G38_03325) 700719..701018 + 300 WP_034872120.1 PTS sugar transporter subunit IIB -
P0G38_RS03330 (P0G38_03330) 701020..701361 + 342 WP_061053195.1 PTS lactose/cellobiose transporter subunit IIA -
P0G38_RS03335 (P0G38_03335) 701518..702852 + 1335 WP_275854033.1 hypothetical protein -
P0G38_RS03340 (P0G38_03340) 702983..703201 + 219 WP_275854034.1 helix-turn-helix transcriptional regulator -
P0G38_RS03345 (P0G38_03345) 703809..704582 + 774 WP_275854035.1 Fic family protein -
P0G38_RS03350 (P0G38_03350) 704728..705393 + 666 WP_252704509.1 Fic family protein -
P0G38_RS03355 (P0G38_03355) 705650..706015 - 366 WP_159160750.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
P0G38_RS03360 (P0G38_03360) 706005..706235 - 231 WP_159160751.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
P0G38_RS03365 (P0G38_03365) 706849..708213 + 1365 WP_275854036.1 guanine deaminase -
P0G38_RS03370 (P0G38_03370) 708254..709574 + 1321 Protein_631 solute carrier family 23 protein -
P0G38_RS03375 (P0G38_03375) 709593..710894 - 1302 WP_275854037.1 ISL3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 703809..716392 12583


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-115)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 14141.18 Da        Isoelectric Point: 9.6731

>T274051 WP_159160750.1 NZ_CP119393:c706015-705650 [Enterococcus casseliflavus]
MNYKPRQRDIVILDFEPSKGYEVRKRRPALVLSKDTYNSATNLIIVCPITTSDKERPFLVPIQSDKLKSNDSRPSKVNTL
QVFSLDYTQAANRNVKYIDTLDEEIFFDIAQRFLKNFSFPF

Download         Length: 366 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8352.54 Da        Isoelectric Point: 4.3776

>AT274051 WP_159160751.1 NZ_CP119393:c706235-706005 [Enterococcus casseliflavus]
MTSTKTRKQGNSLVITIPAKLGIKEGEEFLIIKKQNGTVALIPKVEDFFDTAQEGEFSLPELAIDYTPQGGELNEL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References