Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 6265188..6265792 Replicon chromosome
Accession NZ_CP119371
Organism Pseudomonas sp. CBSPCAW29

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag P0D95_RS28715 Protein ID WP_258346945.1
Coordinates 6265188..6265439 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag P0D95_RS28720 Protein ID WP_258346946.1
Coordinates 6265436..6265792 (+) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P0D95_RS28705 (P0D95_28705) 6263323..6263859 - 537 WP_275713400.1 condensation domain-containing protein -
P0D95_RS28710 (P0D95_28710) 6264015..6264998 - 984 WP_258346944.1 TauD/TfdA family dioxygenase -
P0D95_RS28715 (P0D95_28715) 6265188..6265439 + 252 WP_258346945.1 type II toxin-antitoxin system HicA family toxin Toxin
P0D95_RS28720 (P0D95_28720) 6265436..6265792 + 357 WP_258346946.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
P0D95_RS28725 (P0D95_28725) 6265793..6266965 - 1173 WP_258346947.1 MFS transporter -
P0D95_RS28730 (P0D95_28730) 6267101..6267685 + 585 WP_258346948.1 TetR/AcrR family transcriptional regulator -
P0D95_RS28735 (P0D95_28735) 6268600..6270108 - 1509 WP_258346949.1 MDR family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-76)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9509.99 Da        Isoelectric Point: 10.3760

>T274044 WP_258346945.1 NZ_CP119371:6265188-6265439 [Pseudomonas sp. CBSPCAW29]
VSKNEKLLAKLLNEQSAFTWAERVTLLRRLGYTQIEGAGSRVRFDIGDPSAMITLHKPHPGNELKHYIRRQIIEQLKSGE
LIQ

Download         Length: 252 bp

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 12821.70 Da        Isoelectric Point: 6.8428

>AT274044 WP_258346946.1 NZ_CP119371:6265436-6265792 [Pseudomonas sp. CBSPCAW29]
VNNQLKHKGYIGSIEASLEDNCLFGKLLFIKALVSYEGKTVAELDTAFCTAVDDYIETCMALGQTPEKPCKGSFNVRVGH
DLHLAAALAATRQKVTLNDLTRQALNEFLQHRGALVAG

Download         Length: 357 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References