Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2741573..2742187 Replicon chromosome
Accession NZ_CP119370
Organism Pseudomonas sp. CBSPCBW29

Toxin (Protein)


Gene name hicA Uniprot ID A0A1R0GDL0
Locus tag P0D90_RS12375 Protein ID WP_026077965.1
Coordinates 2741999..2742187 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag P0D90_RS12370 Protein ID WP_258347129.1
Coordinates 2741573..2741977 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P0D90_RS12345 (P0D90_12345) 2736589..2737461 + 873 WP_258347125.1 urea transporter -
P0D90_RS12350 (P0D90_12350) 2737493..2738317 + 825 WP_258347126.1 ion transporter -
P0D90_RS12355 (P0D90_12355) 2738423..2739427 + 1005 WP_258347127.1 sulfate ABC transporter substrate-binding protein -
P0D90_RS12360 (P0D90_12360) 2739585..2740199 - 615 WP_258347128.1 DUF5666 domain-containing protein -
P0D90_RS12365 (P0D90_12365) 2740378..2741572 + 1195 Protein_2452 MFS transporter -
P0D90_RS12370 (P0D90_12370) 2741573..2741977 - 405 WP_258347129.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
P0D90_RS12375 (P0D90_12375) 2741999..2742187 - 189 WP_026077965.1 type II toxin-antitoxin system HicA family toxin Toxin
P0D90_RS12380 (P0D90_12380) 2742403..2743281 + 879 WP_258347130.1 LysR family transcriptional regulator -
P0D90_RS12385 (P0D90_12385) 2743364..2744848 - 1485 WP_258347131.1 M10 family metallopeptidase C-terminal domain-containing protein -
P0D90_RS12390 (P0D90_12390) 2745195..2745944 - 750 WP_258347132.1 phosphonate metabolism protein PhnP -
P0D90_RS12395 (P0D90_12395) 2745935..2746498 - 564 WP_258347133.1 phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7196.40 Da        Isoelectric Point: 11.2000

>T274039 WP_026077965.1 NZ_CP119370:c2742187-2741999 [Pseudomonas sp. CBSPCBW29]
VQSRLLIKELQEAGWVLDRVTGSHHLFTHRYNPYTIPVPHPKKDLPMGTVRSIRKRAGLFSF

Download         Length: 189 bp

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14776.83 Da        Isoelectric Point: 4.5011

>AT274039 WP_258347129.1 NZ_CP119370:c2741977-2741573 [Pseudomonas sp. CBSPCBW29]
MQYPICIEWGDDFVATGIQIPDIPGAVTAGDSFEEAYNAAVEVAHIMLQEIAAEGRAIPMPTSVAAHHDNEDYAGMGWGM
LELDISPYLGKTEKVNVTLPGYVIQRIDRYVREHKVKSRSSFLADAALEKLVRL

Download         Length: 405 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1R0GDL0

Antitoxin

Source ID Structure

References