Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 2426405..2427009 Replicon chromosome
Accession NZ_CP119370
Organism Pseudomonas sp. CBSPCBW29

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag P0D90_RS11020 Protein ID WP_258346945.1
Coordinates 2426405..2426656 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag P0D90_RS11025 Protein ID WP_258346946.1
Coordinates 2426653..2427009 (+) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P0D90_RS11010 (P0D90_11010) 2424540..2425076 - 537 WP_275713400.1 condensation domain-containing protein -
P0D90_RS11015 (P0D90_11015) 2425232..2426215 - 984 WP_258346944.1 TauD/TfdA family dioxygenase -
P0D90_RS11020 (P0D90_11020) 2426405..2426656 + 252 WP_258346945.1 type II toxin-antitoxin system HicA family toxin Toxin
P0D90_RS11025 (P0D90_11025) 2426653..2427009 + 357 WP_258346946.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
P0D90_RS11030 (P0D90_11030) 2427010..2428182 - 1173 WP_258346947.1 MFS transporter -
P0D90_RS11035 (P0D90_11035) 2428318..2428902 + 585 WP_258346948.1 TetR/AcrR family transcriptional regulator -
P0D90_RS11040 (P0D90_11040) 2429815..2431323 - 1509 WP_258346949.1 MDR family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-76)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9509.99 Da        Isoelectric Point: 10.3760

>T274038 WP_258346945.1 NZ_CP119370:2426405-2426656 [Pseudomonas sp. CBSPCBW29]
VSKNEKLLAKLLNEQSAFTWAERVTLLRRLGYTQIEGAGSRVRFDIGDPSAMITLHKPHPGNELKHYIRRQIIEQLKSGE
LIQ

Download         Length: 252 bp

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 12821.70 Da        Isoelectric Point: 6.8428

>AT274038 WP_258346946.1 NZ_CP119370:2426653-2427009 [Pseudomonas sp. CBSPCBW29]
VNNQLKHKGYIGSIEASLEDNCLFGKLLFIKALVSYEGKTVAELDTAFCTAVDDYIETCMALGQTPEKPCKGSFNVRVGH
DLHLAAALAATRQKVTLNDLTRQALNEFLQHRGALVAG

Download         Length: 357 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References