Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 3668533..3669137 Replicon chromosome
Accession NZ_CP119369
Organism Pseudomonas sp. CBSPAW29

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag P0D92_RS17105 Protein ID WP_258346945.1
Coordinates 3668886..3669137 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag P0D92_RS17100 Protein ID WP_258346946.1
Coordinates 3668533..3668889 (-) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P0D92_RS17085 (P0D92_17085) 3664222..3665730 + 1509 WP_258346949.1 MDR family MFS transporter -
P0D92_RS17090 (P0D92_17090) 3666640..3667224 - 585 WP_258346948.1 TetR/AcrR family transcriptional regulator -
P0D92_RS17095 (P0D92_17095) 3667360..3668532 + 1173 WP_258346947.1 MFS transporter -
P0D92_RS17100 (P0D92_17100) 3668533..3668889 - 357 WP_258346946.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
P0D92_RS17105 (P0D92_17105) 3668886..3669137 - 252 WP_258346945.1 type II toxin-antitoxin system HicA family toxin Toxin
P0D92_RS17110 (P0D92_17110) 3669327..3670310 + 984 WP_258346944.1 TauD/TfdA family dioxygenase -
P0D92_RS17115 (P0D92_17115) 3670464..3670934 + 471 WP_275753731.1 condensation domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-76)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9509.99 Da        Isoelectric Point: 10.3760

>T274036 WP_258346945.1 NZ_CP119369:c3669137-3668886 [Pseudomonas sp. CBSPAW29]
VSKNEKLLAKLLNEQSAFTWAERVTLLRRLGYTQIEGAGSRVRFDIGDPSAMITLHKPHPGNELKHYIRRQIIEQLKSGE
LIQ

Download         Length: 252 bp

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 12821.70 Da        Isoelectric Point: 6.8428

>AT274036 WP_258346946.1 NZ_CP119369:c3668889-3668533 [Pseudomonas sp. CBSPAW29]
VNNQLKHKGYIGSIEASLEDNCLFGKLLFIKALVSYEGKTVAELDTAFCTAVDDYIETCMALGQTPEKPCKGSFNVRVGH
DLHLAAALAATRQKVTLNDLTRQALNEFLQHRGALVAG

Download         Length: 357 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References