Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3353363..3353977 Replicon chromosome
Accession NZ_CP119369
Organism Pseudomonas sp. CBSPAW29

Toxin (Protein)


Gene name hicA Uniprot ID A0A1R0GDL0
Locus tag P0D92_RS15725 Protein ID WP_026077965.1
Coordinates 3353363..3353551 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag P0D92_RS15730 Protein ID WP_258347129.1
Coordinates 3353573..3353977 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P0D92_RS15705 (P0D92_15705) 3349053..3349616 + 564 WP_258347133.1 phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN -
P0D92_RS15710 (P0D92_15710) 3349607..3350356 + 750 WP_258347132.1 phosphonate metabolism protein PhnP -
P0D92_RS15715 (P0D92_15715) 3350703..3352187 + 1485 WP_258347131.1 M10 family metallopeptidase C-terminal domain-containing protein -
P0D92_RS15720 (P0D92_15720) 3352270..3353147 - 878 Protein_3091 LysR family transcriptional regulator -
P0D92_RS15725 (P0D92_15725) 3353363..3353551 + 189 WP_026077965.1 type II toxin-antitoxin system HicA family toxin Toxin
P0D92_RS15730 (P0D92_15730) 3353573..3353977 + 405 WP_258347129.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
P0D92_RS15735 (P0D92_15735) 3353978..3355174 - 1197 WP_167663625.1 MFS transporter -
P0D92_RS15740 (P0D92_15740) 3355353..3355967 + 615 WP_258347128.1 DUF5666 domain-containing protein -
P0D92_RS15745 (P0D92_15745) 3356125..3357128 - 1004 Protein_3096 sulfate ABC transporter substrate-binding protein -
P0D92_RS15750 (P0D92_15750) 3357234..3358058 - 825 WP_258347126.1 ion transporter -
P0D92_RS15755 (P0D92_15755) 3358090..3358962 - 873 WP_258347125.1 urea transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7196.40 Da        Isoelectric Point: 11.2000

>T274035 WP_026077965.1 NZ_CP119369:3353363-3353551 [Pseudomonas sp. CBSPAW29]
VQSRLLIKELQEAGWVLDRVTGSHHLFTHRYNPYTIPVPHPKKDLPMGTVRSIRKRAGLFSF

Download         Length: 189 bp

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14776.83 Da        Isoelectric Point: 4.5011

>AT274035 WP_258347129.1 NZ_CP119369:3353573-3353977 [Pseudomonas sp. CBSPAW29]
MQYPICIEWGDDFVATGIQIPDIPGAVTAGDSFEEAYNAAVEVAHIMLQEIAAEGRAIPMPTSVAAHHDNEDYAGMGWGM
LELDISPYLGKTEKVNVTLPGYVIQRIDRYVREHKVKSRSSFLADAALEKLVRL

Download         Length: 405 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1R0GDL0

Antitoxin

Source ID Structure

References