Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2005803..2006417 Replicon chromosome
Accession NZ_CP119368
Organism Pseudomonas sp. CBSPCGW29

Toxin (Protein)


Gene name hicA Uniprot ID A0A1R0GDL0
Locus tag P0D94_RS09720 Protein ID WP_026077965.1
Coordinates 2005803..2005991 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag P0D94_RS09725 Protein ID WP_258347129.1
Coordinates 2006013..2006417 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P0D94_RS09700 (P0D94_09700) 2001494..2002057 + 564 WP_258347133.1 phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN -
P0D94_RS09705 (P0D94_09705) 2002048..2002857 + 810 WP_275711789.1 phosphonate metabolism protein PhnP -
P0D94_RS09710 (P0D94_09710) 2003142..2004626 + 1485 WP_258347131.1 M10 family metallopeptidase C-terminal domain-containing protein -
P0D94_RS09715 (P0D94_09715) 2004709..2005587 - 879 WP_258347130.1 LysR family transcriptional regulator -
P0D94_RS09720 (P0D94_09720) 2005803..2005991 + 189 WP_026077965.1 type II toxin-antitoxin system HicA family toxin Toxin
P0D94_RS09725 (P0D94_09725) 2006013..2006417 + 405 WP_258347129.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
P0D94_RS09730 (P0D94_09730) 2006418..2007614 - 1197 WP_167663625.1 MFS transporter -
P0D94_RS09735 (P0D94_09735) 2007793..2008407 + 615 WP_258347128.1 DUF5666 domain-containing protein -
P0D94_RS09740 (P0D94_09740) 2008565..2009568 - 1004 Protein_1922 sulfate ABC transporter substrate-binding protein -
P0D94_RS09745 (P0D94_09745) 2009674..2010498 - 825 WP_258347126.1 ion transporter -
P0D94_RS09750 (P0D94_09750) 2010530..2011402 - 873 WP_258347125.1 urea transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7196.40 Da        Isoelectric Point: 11.2000

>T274031 WP_026077965.1 NZ_CP119368:2005803-2005991 [Pseudomonas sp. CBSPCGW29]
VQSRLLIKELQEAGWVLDRVTGSHHLFTHRYNPYTIPVPHPKKDLPMGTVRSIRKRAGLFSF

Download         Length: 189 bp

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14776.83 Da        Isoelectric Point: 4.5011

>AT274031 WP_258347129.1 NZ_CP119368:2006013-2006417 [Pseudomonas sp. CBSPCGW29]
MQYPICIEWGDDFVATGIQIPDIPGAVTAGDSFEEAYNAAVEVAHIMLQEIAAEGRAIPMPTSVAAHHDNEDYAGMGWGM
LELDISPYLGKTEKVNVTLPGYVIQRIDRYVREHKVKSRSSFLADAALEKLVRL

Download         Length: 405 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1R0GDL0

Antitoxin

Source ID Structure

References