Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 6354187..6354801 Replicon chromosome
Accession NZ_CP119366
Organism Pseudomonas sp. CBSPBW29

Toxin (Protein)


Gene name hicA Uniprot ID A0A1R0GDL0
Locus tag P0D91_RS29610 Protein ID WP_026077965.1
Coordinates 6354187..6354375 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag P0D91_RS29615 Protein ID WP_258347129.1
Coordinates 6354397..6354801 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P0D91_RS29590 (P0D91_29590) 6349877..6350440 + 564 WP_258347133.1 phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN -
P0D91_RS29595 (P0D91_29595) 6350431..6351180 + 750 WP_258347132.1 phosphonate metabolism protein PhnP -
P0D91_RS29600 (P0D91_29600) 6351527..6353011 + 1485 WP_258347131.1 M10 family metallopeptidase C-terminal domain-containing protein -
P0D91_RS29605 (P0D91_29605) 6353094..6353971 - 878 Protein_5852 LysR family transcriptional regulator -
P0D91_RS29610 (P0D91_29610) 6354187..6354375 + 189 WP_026077965.1 type II toxin-antitoxin system HicA family toxin Toxin
P0D91_RS29615 (P0D91_29615) 6354397..6354801 + 405 WP_258347129.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
P0D91_RS29620 (P0D91_29620) 6354802..6355998 - 1197 WP_167663625.1 MFS transporter -
P0D91_RS29625 (P0D91_29625) 6356177..6356791 + 615 WP_258347128.1 DUF5666 domain-containing protein -
P0D91_RS29630 (P0D91_29630) 6356949..6357952 - 1004 Protein_5857 sulfate ABC transporter substrate-binding protein -
P0D91_RS29635 (P0D91_29635) 6358058..6358882 - 825 WP_258347126.1 ion transporter -
P0D91_RS29640 (P0D91_29640) 6358914..6359786 - 873 WP_258347125.1 urea transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7196.40 Da        Isoelectric Point: 11.2000

>T274024 WP_026077965.1 NZ_CP119366:6354187-6354375 [Pseudomonas sp. CBSPBW29]
VQSRLLIKELQEAGWVLDRVTGSHHLFTHRYNPYTIPVPHPKKDLPMGTVRSIRKRAGLFSF

Download         Length: 189 bp

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14776.83 Da        Isoelectric Point: 4.5011

>AT274024 WP_258347129.1 NZ_CP119366:6354397-6354801 [Pseudomonas sp. CBSPBW29]
MQYPICIEWGDDFVATGIQIPDIPGAVTAGDSFEEAYNAAVEVAHIMLQEIAAEGRAIPMPTSVAAHHDNEDYAGMGWGM
LELDISPYLGKTEKVNVTLPGYVIQRIDRYVREHKVKSRSSFLADAALEKLVRL

Download         Length: 405 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1R0GDL0

Antitoxin

Source ID Structure

References