Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2144703..2145217 Replicon chromosome
Accession NZ_CP119344
Organism Staphylococcus aureus strain N29CSA11

Toxin (Protein)


Gene name TsdT Uniprot ID A0A641A3V2
Locus tag P1A16_RS10585 Protein ID WP_000581793.1
Coordinates 2144703..2144912 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag P1A16_RS10590 Protein ID WP_000138932.1
Coordinates 2144924..2145217 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1A16_RS10565 (P1A16_10565) 2140212..2141570 - 1359 WP_000611482.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
P1A16_RS10570 (P1A16_10570) 2141585..2142655 - 1071 WP_000159627.1 D-alanine--D-alanine ligase -
P1A16_RS10575 (P1A16_10575) 2142973..2144175 + 1203 WP_031590208.1 FtsW/RodA/SpoVE family cell cycle protein -
P1A16_RS10580 (P1A16_10580) 2144438..2144575 - 138 WP_000828354.1 Lmo0850 family protein -
P1A16_RS10585 (P1A16_10585) 2144703..2144912 - 210 WP_000581793.1 heavy metal-associated domain-containing protein Toxin
P1A16_RS10590 (P1A16_10590) 2144924..2145217 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
P1A16_RS10595 (P1A16_10595) 2145383..2146867 + 1485 WP_000571549.1 cardiolipin synthase -
P1A16_RS10600 (P1A16_10600) 2146895..2147542 + 648 WP_031590210.1 HD domain-containing protein -
P1A16_RS10605 (P1A16_10605) 2148156..2149028 - 873 WP_000725802.1 membrane protein insertase YidC -
P1A16_RS10610 (P1A16_10610) 2149114..2149755 - 642 WP_000483155.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7809.75 Da        Isoelectric Point: 4.1008

>T274017 WP_000581793.1 NZ_CP119344:c2144912-2144703 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVI

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT274017 WP_000138932.1 NZ_CP119344:c2145217-2144924 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A641A3V2

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References