Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2124963..2125492 Replicon chromosome
Accession NZ_CP119344
Organism Staphylococcus aureus strain N29CSA11

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag P1A16_RS10495 Protein ID WP_000621175.1
Coordinates 2124963..2125325 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag P1A16_RS10500 Protein ID WP_000948331.1
Coordinates 2125322..2125492 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1A16_RS10475 (P1A16_10475) 2121941..2122711 - 771 WP_001041102.1 RNA polymerase sigma factor SigB -
P1A16_RS10480 (P1A16_10480) 2122686..2123165 - 480 WP_001190829.1 anti-sigma B factor RsbW -
P1A16_RS10485 (P1A16_10485) 2123167..2123493 - 327 WP_001052491.1 anti-sigma factor antagonist -
P1A16_RS10490 (P1A16_10490) 2123612..2124613 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
P1A16_RS10495 (P1A16_10495) 2124963..2125325 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
P1A16_RS10500 (P1A16_10500) 2125322..2125492 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
P1A16_RS10505 (P1A16_10505) 2125577..2126725 - 1149 WP_113342708.1 alanine racemase -
P1A16_RS10510 (P1A16_10510) 2126791..2127150 - 360 WP_000581197.1 holo-ACP synthase -
P1A16_RS10515 (P1A16_10515) 2127154..2127645 - 492 WP_072353916.1 PH domain-containing protein -
P1A16_RS10520 (P1A16_10520) 2127632..2129215 - 1584 WP_001294626.1 PH domain-containing protein -
P1A16_RS10525 (P1A16_10525) 2129208..2129687 - 480 WP_031590204.1 hypothetical protein -
P1A16_RS10530 (P1A16_10530) 2129896..2130456 - 561 WP_001092410.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T274016 WP_000621175.1 NZ_CP119344:c2125325-2124963 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT274016 WP_000948331.1 NZ_CP119344:c2125492-2125322 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References