Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1958402..1959178 Replicon chromosome
Accession NZ_CP119344
Organism Staphylococcus aureus strain N29CSA11

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag P1A16_RS09535 Protein ID WP_000031108.1
Coordinates 1958402..1958554 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag P1A16_RS09540 Protein ID WP_001251230.1
Coordinates 1958579..1959178 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1A16_RS09520 (P1A16_09520) 1954317..1955138 + 822 WP_000669376.1 RluA family pseudouridine synthase -
P1A16_RS09525 (P1A16_09525) 1955590..1956975 - 1386 WP_000116229.1 class II fumarate hydratase -
P1A16_RS09530 (P1A16_09530) 1957171..1957566 - 396 WP_000901023.1 hypothetical protein -
P1A16_RS09535 (P1A16_09535) 1958402..1958554 - 153 WP_000031108.1 SAS053 family protein Toxin
P1A16_RS09540 (P1A16_09540) 1958579..1959178 - 600 WP_001251230.1 hypothetical protein Antitoxin
P1A16_RS09545 (P1A16_09545) 1959337..1959807 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
P1A16_RS09550 (P1A16_09550) 1959812..1960939 - 1128 WP_031590038.1 tRNA epoxyqueuosine(34) reductase QueG -
P1A16_RS09555 (P1A16_09555) 1961090..1961812 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
P1A16_RS09560 (P1A16_09560) 1961805..1963262 - 1458 WP_000649908.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T274015 WP_000031108.1 NZ_CP119344:c1958554-1958402 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22369.51 Da        Isoelectric Point: 4.9728

>AT274015 WP_001251230.1 NZ_CP119344:c1959178-1958579 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKYAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure

References