Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2201775..2202289 Replicon chromosome
Accession NZ_CP119341
Organism Staphylococcus aureus strain N29CSA02

Toxin (Protein)


Gene name TsdT Uniprot ID A0A641A3V2
Locus tag P1A17_RS10990 Protein ID WP_000581793.1
Coordinates 2201775..2201984 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag P1A17_RS10995 Protein ID WP_000138932.1
Coordinates 2201996..2202289 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1A17_RS10970 (2197284) 2197284..2198642 - 1359 WP_000611482.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
P1A17_RS10975 (2198657) 2198657..2199727 - 1071 WP_000159627.1 D-alanine--D-alanine ligase -
P1A17_RS10980 (2200045) 2200045..2201247 + 1203 WP_275600312.1 FtsW/RodA/SpoVE family cell cycle protein -
P1A17_RS10985 (2201510) 2201510..2201647 - 138 WP_000828354.1 Lmo0850 family protein -
P1A17_RS10990 (2201775) 2201775..2201984 - 210 WP_000581793.1 heavy metal-associated domain-containing protein Toxin
P1A17_RS10995 (2201996) 2201996..2202289 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
P1A17_RS11000 (2202455) 2202455..2203939 + 1485 WP_000571549.1 cardiolipin synthase -
P1A17_RS11005 (2203967) 2203967..2204614 + 648 WP_031590210.1 HD domain-containing protein -
P1A17_RS11010 (2205228) 2205228..2206100 - 873 WP_000725802.1 membrane protein insertase YidC -
P1A17_RS11015 (2206186) 2206186..2206827 - 642 WP_000483155.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7809.75 Da        Isoelectric Point: 4.1008

>T274008 WP_000581793.1 NZ_CP119341:c2201984-2201775 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVI

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT274008 WP_000138932.1 NZ_CP119341:c2202289-2201996 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A641A3V2

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References