Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2182035..2182564 Replicon chromosome
Accession NZ_CP119341
Organism Staphylococcus aureus strain N29CSA02

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag P1A17_RS10900 Protein ID WP_000621175.1
Coordinates 2182035..2182397 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag P1A17_RS10905 Protein ID WP_000948331.1
Coordinates 2182394..2182564 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1A17_RS10880 (2178990) 2178990..2179760 - 771 WP_001041102.1 RNA polymerase sigma factor SigB -
P1A17_RS10885 (2179735) 2179735..2180214 - 480 WP_001190829.1 anti-sigma B factor RsbW -
P1A17_RS10890 (2180216) 2180216..2180542 - 327 WP_001052491.1 anti-sigma factor antagonist -
P1A17_RS10895 (2180661) 2180661..2181662 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
P1A17_RS10900 (2182035) 2182035..2182397 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
P1A17_RS10905 (2182394) 2182394..2182564 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
P1A17_RS10910 (2182649) 2182649..2183797 - 1149 WP_001281154.1 alanine racemase -
P1A17_RS10915 (2183863) 2183863..2184222 - 360 WP_000581197.1 holo-ACP synthase -
P1A17_RS10920 (2184226) 2184226..2184717 - 492 WP_072353916.1 PH domain-containing protein -
P1A17_RS10925 (2184704) 2184704..2186287 - 1584 WP_001294626.1 PH domain-containing protein -
P1A17_RS10930 (2186280) 2186280..2186759 - 480 WP_031590204.1 hypothetical protein -
P1A17_RS10935 (2186968) 2186968..2187528 - 561 WP_001092410.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T274007 WP_000621175.1 NZ_CP119341:c2182397-2182035 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT274007 WP_000948331.1 NZ_CP119341:c2182564-2182394 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References