Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2155025..2155554 Replicon chromosome
Accession NZ_CP119340
Organism Staphylococcus aureus strain N28CSA05

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag P1A15_RS10650 Protein ID WP_000621175.1
Coordinates 2155025..2155387 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag P1A15_RS10655 Protein ID WP_000948331.1
Coordinates 2155384..2155554 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1A15_RS10630 (P1A15_10630) 2152003..2152773 - 771 WP_001041102.1 RNA polymerase sigma factor SigB -
P1A15_RS10635 (P1A15_10635) 2152748..2153227 - 480 WP_001190829.1 anti-sigma B factor RsbW -
P1A15_RS10640 (P1A15_10640) 2153229..2153555 - 327 WP_001052491.1 anti-sigma factor antagonist -
P1A15_RS10645 (P1A15_10645) 2153674..2154675 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
P1A15_RS10650 (P1A15_10650) 2155025..2155387 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
P1A15_RS10655 (P1A15_10655) 2155384..2155554 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
P1A15_RS10660 (P1A15_10660) 2155639..2156787 - 1149 WP_113342708.1 alanine racemase -
P1A15_RS10665 (P1A15_10665) 2156853..2157212 - 360 WP_000581197.1 holo-ACP synthase -
P1A15_RS10670 (P1A15_10670) 2157216..2157707 - 492 WP_072353916.1 PH domain-containing protein -
P1A15_RS10675 (P1A15_10675) 2157694..2159277 - 1584 WP_001294626.1 PH domain-containing protein -
P1A15_RS10680 (P1A15_10680) 2159270..2159749 - 480 WP_031590204.1 hypothetical protein -
P1A15_RS10685 (P1A15_10685) 2159958..2160518 - 561 WP_001092410.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T273992 WP_000621175.1 NZ_CP119340:c2155387-2155025 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT273992 WP_000948331.1 NZ_CP119340:c2155554-2155384 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References