Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2170319..2170833 Replicon chromosome
Accession NZ_CP119338
Organism Staphylococcus aureus strain N09HSA11

Toxin (Protein)


Gene name TsdT Uniprot ID A0A641A3V2
Locus tag P1A14_RS10715 Protein ID WP_000581793.1
Coordinates 2170319..2170528 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag P1A14_RS10720 Protein ID WP_000138932.1
Coordinates 2170540..2170833 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1A14_RS10695 (P1A14_10695) 2165828..2167186 - 1359 WP_000611482.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
P1A14_RS10700 (P1A14_10700) 2167201..2168271 - 1071 WP_000159627.1 D-alanine--D-alanine ligase -
P1A14_RS10705 (P1A14_10705) 2168589..2169791 + 1203 WP_031590208.1 FtsW/RodA/SpoVE family cell cycle protein -
P1A14_RS10710 (P1A14_10710) 2170054..2170191 - 138 WP_000828354.1 Lmo0850 family protein -
P1A14_RS10715 (P1A14_10715) 2170319..2170528 - 210 WP_000581793.1 heavy metal-associated domain-containing protein Toxin
P1A14_RS10720 (P1A14_10720) 2170540..2170833 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
P1A14_RS10725 (P1A14_10725) 2170999..2172483 + 1485 WP_000571549.1 cardiolipin synthase -
P1A14_RS10730 (P1A14_10730) 2172511..2173158 + 648 WP_031590210.1 HD domain-containing protein -
P1A14_RS10735 (P1A14_10735) 2173772..2174644 - 873 WP_000725802.1 membrane protein insertase YidC -
P1A14_RS10740 (P1A14_10740) 2174730..2175371 - 642 WP_000483155.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7809.75 Da        Isoelectric Point: 4.1008

>T273984 WP_000581793.1 NZ_CP119338:c2170528-2170319 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVI

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT273984 WP_000138932.1 NZ_CP119338:c2170833-2170540 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A641A3V2

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References