Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2150579..2151108 Replicon chromosome
Accession NZ_CP119338
Organism Staphylococcus aureus strain N09HSA11

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag P1A14_RS10625 Protein ID WP_000621175.1
Coordinates 2150579..2150941 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag P1A14_RS10630 Protein ID WP_000948331.1
Coordinates 2150938..2151108 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1A14_RS10605 (P1A14_10605) 2147557..2148327 - 771 WP_001041102.1 RNA polymerase sigma factor SigB -
P1A14_RS10610 (P1A14_10610) 2148302..2148781 - 480 WP_001190829.1 anti-sigma B factor RsbW -
P1A14_RS10615 (P1A14_10615) 2148783..2149109 - 327 WP_001052491.1 anti-sigma factor antagonist -
P1A14_RS10620 (P1A14_10620) 2149228..2150229 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
P1A14_RS10625 (P1A14_10625) 2150579..2150941 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
P1A14_RS10630 (P1A14_10630) 2150938..2151108 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
P1A14_RS10635 (P1A14_10635) 2151193..2152341 - 1149 WP_001281154.1 alanine racemase -
P1A14_RS10640 (P1A14_10640) 2152407..2152766 - 360 WP_000581197.1 holo-ACP synthase -
P1A14_RS10645 (P1A14_10645) 2152770..2153261 - 492 WP_072353916.1 PH domain-containing protein -
P1A14_RS10650 (P1A14_10650) 2153248..2154831 - 1584 WP_001294626.1 PH domain-containing protein -
P1A14_RS10655 (P1A14_10655) 2154824..2155303 - 480 WP_031590204.1 hypothetical protein -
P1A14_RS10660 (P1A14_10660) 2155512..2156072 - 561 WP_001092410.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T273983 WP_000621175.1 NZ_CP119338:c2150941-2150579 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT273983 WP_000948331.1 NZ_CP119338:c2151108-2150938 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References