Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 938769..939246 Replicon chromosome
Accession NZ_CP119338
Organism Staphylococcus aureus strain N09HSA11

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag P1A14_RS04580 Protein ID WP_000052076.1
Coordinates 938769..938957 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag P1A14_RS04585 Protein ID WP_001059690.1
Coordinates 938986..939246 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1A14_RS04550 (P1A14_04550) 934804..935280 + 477 WP_000824477.1 hypothetical protein -
P1A14_RS04555 (P1A14_04555) 935621..936307 + 687 WP_001641381.1 thermonuclease family protein -
P1A14_RS04560 (P1A14_04560) 936664..936864 + 201 WP_001059082.1 cold-shock protein -
P1A14_RS04565 (P1A14_04565) 937360..937578 - 219 WP_000005887.1 hypothetical protein -
P1A14_RS04570 (P1A14_04570) 937640..937924 - 285 WP_031590186.1 hypothetical protein -
P1A14_RS04575 (P1A14_04575) 938012..938581 - 570 WP_001106652.1 lipoprotein N-acylation protein LnsA -
P1A14_RS04580 (P1A14_04580) 938769..938957 - 189 WP_000052076.1 hypothetical protein Toxin
P1A14_RS04585 (P1A14_04585) 938986..939246 - 261 WP_001059690.1 hypothetical protein Antitoxin
P1A14_RS04590 (P1A14_04590) 939587..939790 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
P1A14_RS04595 (P1A14_04595) 939787..940023 - 237 WP_000368687.1 hypothetical protein -
P1A14_RS04600 (P1A14_04600) 940248..940829 + 582 WP_001140697.1 histidine phosphatase family protein -
P1A14_RS04605 (P1A14_04605) 940902..941519 - 618 WP_000255553.1 LysE/ArgO family amino acid transporter -
P1A14_RS04610 (P1A14_04610) 941675..942169 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
P1A14_RS04615 (P1A14_04615) 942568..942990 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
P1A14_RS04620 (P1A14_04620) 943138..943854 + 717 WP_031589686.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T273980 WP_000052076.1 NZ_CP119338:c938957-938769 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T273980 NZ_CP119338:c938957-938769 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT273980 WP_001059690.1 NZ_CP119338:c939246-938986 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT273980 NZ_CP119338:c939246-938986 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTATATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References