Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5029718..5030343 Replicon chromosome
Accession NZ_CP119332
Organism Klebsiella pneumoniae strain CQ22WZ0036

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag OMP07_RS24935 Protein ID WP_002882817.1
Coordinates 5029718..5030101 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag OMP07_RS24940 Protein ID WP_004150355.1
Coordinates 5030101..5030343 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OMP07_RS24920 (OMP07_24920) 5027084..5027986 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
OMP07_RS24925 (OMP07_24925) 5027983..5028618 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
OMP07_RS24930 (OMP07_24930) 5028615..5029544 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
OMP07_RS24935 (OMP07_24935) 5029718..5030101 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
OMP07_RS24940 (OMP07_24940) 5030101..5030343 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
OMP07_RS24945 (OMP07_24945) 5030548..5031465 + 918 WP_002882812.1 alpha/beta hydrolase -
OMP07_RS24950 (OMP07_24950) 5031479..5032420 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
OMP07_RS24955 (OMP07_24955) 5032465..5032902 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
OMP07_RS24960 (OMP07_24960) 5032899..5033759 - 861 WP_002882807.1 virulence factor BrkB family protein -
OMP07_RS24965 (OMP07_24965) 5033753..5034352 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T273967 WP_002882817.1 NZ_CP119332:c5030101-5029718 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT273967 WP_004150355.1 NZ_CP119332:c5030343-5030101 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References