Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4446181..4446991 Replicon chromosome
Accession NZ_CP119332
Organism Klebsiella pneumoniae strain CQ22WZ0036

Toxin (Protein)


Gene name KacT Uniprot ID A0A0H3GMP0
Locus tag OMP07_RS22135 Protein ID WP_002887280.1
Coordinates 4446181..4446714 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag OMP07_RS22140 Protein ID WP_002887278.1
Coordinates 4446725..4446991 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OMP07_RS22130 (OMP07_22130) 4445012..4446133 + 1122 WP_002887282.1 cupin domain-containing protein -
OMP07_RS22135 (OMP07_22135) 4446181..4446714 - 534 WP_002887280.1 type II toxin-antitoxin system toxin KacT Toxin
OMP07_RS22140 (OMP07_22140) 4446725..4446991 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
OMP07_RS22145 (OMP07_22145) 4447094..4448527 - 1434 WP_002887275.1 Cu(+)/Ag(+) sensor histidine kinase -
OMP07_RS22150 (OMP07_22150) 4448517..4449200 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
OMP07_RS22155 (OMP07_22155) 4449372..4450757 + 1386 WP_002887267.1 efflux transporter outer membrane subunit -
OMP07_RS22160 (OMP07_22160) 4450775..4451119 + 345 WP_002887266.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19838.70 Da        Isoelectric Point: 5.2614

>T273964 WP_002887280.1 NZ_CP119332:c4446714-4446181 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHVMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT273964 WP_002887278.1 NZ_CP119332:c4446991-4446725 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5ZGN
PDB 5XUN

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References