Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
| Location | 4299298..4301020 | Replicon | chromosome |
| Accession | NZ_CP119332 | ||
| Organism | Klebsiella pneumoniae strain CQ22WZ0036 | ||
Toxin (Protein)
| Gene name | mosT | Uniprot ID | D0FZT9 |
| Locus tag | OMP07_RS21405 | Protein ID | WP_000356587.1 |
| Coordinates | 4299298..4300236 (-) | Length | 313 a.a. |
Antitoxin (Protein)
| Gene name | mosA | Uniprot ID | - |
| Locus tag | OMP07_RS21410 | Protein ID | WP_048608544.1 |
| Coordinates | 4300229..4301020 (-) | Length | 264 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OMP07_RS21385 (OMP07_21385) | 4295239..4295751 | - | 513 | WP_172689549.1 | S26 family signal peptidase | - |
| OMP07_RS21390 (OMP07_21390) | 4295735..4296082 | - | 348 | WP_048608540.1 | hypothetical protein | - |
| OMP07_RS21395 (OMP07_21395) | 4296075..4298474 | - | 2400 | WP_048608542.1 | type IV secretion system protein TraC | - |
| OMP07_RS21400 (OMP07_21400) | 4298474..4299166 | - | 693 | WP_001228924.1 | DsbC family protein | - |
| OMP07_RS21405 (OMP07_21405) | 4299298..4300236 | - | 939 | WP_000356587.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| OMP07_RS21410 (OMP07_21410) | 4300229..4301020 | - | 792 | WP_048608544.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| OMP07_RS21415 (OMP07_21415) | 4301241..4301627 | - | 387 | WP_048608546.1 | TraA family conjugative transfer protein | - |
| OMP07_RS21420 (OMP07_21420) | 4301624..4302196 | - | 573 | WP_139175592.1 | type IV conjugative transfer system lipoprotein TraV | - |
| OMP07_RS21425 (OMP07_21425) | 4302271..4303560 | - | 1290 | WP_085285719.1 | TraB/VirB10 family protein | - |
| OMP07_RS21430 (OMP07_21430) | 4303563..4304459 | - | 897 | WP_048608549.1 | type-F conjugative transfer system secretin TraK | - |
| OMP07_RS21435 (OMP07_21435) | 4304443..4305069 | - | 627 | WP_000667170.1 | TraE/TraK family type IV conjugative transfer system protein | - |
| OMP07_RS21440 (OMP07_21440) | 4305066..4305347 | - | 282 | WP_000433889.1 | type IV conjugative transfer system protein TraL | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | sul2 / aph(3'')-Ib / aph(6)-Id / floR | lpxA / lpxD / exeG / lpxC | 3978742..4347257 | 368515 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 313 a.a. Molecular weight: 35548.82 Da Isoelectric Point: 4.9081
>T273963 WP_000356587.1 NZ_CP119332:c4300236-4299298 [Klebsiella pneumoniae]
MDKDSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALINVRAALQRITDRINTQ
PDIRAAFQDNKADELRIVVSSPVATIKIEVSPVARGTLHSAEIMPVQESVEDEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGISREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLIELQK
HFTERDHAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLVNANAE
MDKDSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALINVRAALQRITDRINTQ
PDIRAAFQDNKADELRIVVSSPVATIKIEVSPVARGTLHSAEIMPVQESVEDEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGISREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLIELQK
HFTERDHAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLVNANAE
Download Length: 939 bp
Antitoxin
Download Length: 264 a.a. Molecular weight: 30100.44 Da Isoelectric Point: 9.3513
>AT273963 WP_048608544.1 NZ_CP119332:c4301020-4300229 [Klebsiella pneumoniae]
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLSSGVYYRPDAQGDIKPTWVDAIQALDVQLGVSVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDAIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRIDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLSSGVYYRPDAQGDIKPTWVDAIQALDVQLGVSVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDAIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRIDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG
Download Length: 792 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|