Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 414970..415624 Replicon chromosome
Accession NZ_CP119332
Organism Klebsiella pneumoniae strain CQ22WZ0036

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag OMP07_RS02190 Protein ID WP_004144731.1
Coordinates 415217..415624 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag OMP07_RS02185 Protein ID WP_002916312.1
Coordinates 414970..415236 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OMP07_RS02160 (OMP07_02160) 410126..411559 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
OMP07_RS02165 (OMP07_02165) 411678..412406 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
OMP07_RS02170 (OMP07_02170) 412456..412767 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
OMP07_RS02175 (OMP07_02175) 412931..413590 + 660 WP_002916317.1 hemolysin III family protein -
OMP07_RS02180 (OMP07_02180) 413741..414724 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
OMP07_RS02185 (OMP07_02185) 414970..415236 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
OMP07_RS02190 (OMP07_02190) 415217..415624 + 408 WP_004144731.1 protein YgfX Toxin
OMP07_RS02195 (OMP07_02195) 415631..416152 - 522 WP_002916308.1 flavodoxin FldB -
OMP07_RS02200 (OMP07_02200) 416253..417149 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
OMP07_RS02205 (OMP07_02205) 417172..417885 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OMP07_RS02210 (OMP07_02210) 417891..419624 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T273956 WP_004144731.1 NZ_CP119332:415217-415624 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT273956 WP_002916312.1 NZ_CP119332:414970-415236 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References