Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 1040101..1040903 Replicon chromosome
Accession NZ_CP119327
Organism Staphylococcus sp. NRL 16/872

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag MT340_RS05185 Protein ID WP_243589039.1
Coordinates 1040101..1040562 (-) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag MT340_RS05190 Protein ID WP_243589040.1
Coordinates 1040574..1040903 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MT340_RS05130 (MT340_005130) 1036133..1036693 + 561 WP_243603619.1 alpha/beta hydrolase -
MT340_RS05175 (MT340_005175) 1038050..1039099 - 1050 WP_243589037.1 site-specific integrase -
MT340_RS05180 (MT340_005180) 1039163..1040080 - 918 WP_243589038.1 DUF5067 domain-containing protein -
MT340_RS05185 (MT340_005185) 1040101..1040562 - 462 WP_243589039.1 ImmA/IrrE family metallo-endopeptidase Toxin
MT340_RS05190 (MT340_005190) 1040574..1040903 - 330 WP_243589040.1 helix-turn-helix transcriptional regulator Antitoxin
MT340_RS05195 (MT340_005195) 1041097..1041336 + 240 WP_002484756.1 helix-turn-helix transcriptional regulator -
MT340_RS05200 (MT340_005200) 1041354..1042283 + 930 WP_243589041.1 DUF3102 domain-containing protein -
MT340_RS05205 (MT340_005205) 1042276..1042815 + 540 WP_243589042.1 ORF6C domain-containing protein -
MT340_RS05210 (MT340_005210) 1042853..1043014 + 162 WP_012991008.1 hypothetical protein -
MT340_RS05215 (MT340_005215) 1043007..1043252 - 246 WP_243589043.1 hypothetical protein -
MT340_RS05220 (MT340_005220) 1043306..1043515 + 210 WP_243589044.1 hypothetical protein -
MT340_RS05225 (MT340_005225) 1043529..1043690 + 162 WP_243589045.1 DUF1270 family protein -
MT340_RS05230 (MT340_005230) 1043775..1044008 + 234 WP_243589046.1 hypothetical protein -
MT340_RS05235 (MT340_005235) 1043992..1044477 + 486 WP_243589047.1 siphovirus Gp157 family protein -
MT340_RS05240 (MT340_005240) 1044478..1045155 + 678 WP_243589048.1 ERF family protein -
MT340_RS05245 (MT340_005245) 1045148..1045561 + 414 WP_193624733.1 single-stranded DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1036133..1083253 47120


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(15-118)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-65)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18115.68 Da        Isoelectric Point: 6.4974

>T273953 WP_243589039.1 NZ_CP119327:c1040562-1040101 [Staphylococcus sp. NRL 16/872]
MGLYEKMLIEHDYIEVRETDVMPNDLHGLWLGDLILIKRNLSETRKAEVLYEELAHHKLTYGNILDQSKDINRKFENYAR
RHGYEAALPLRIIVEAHNYGVSSLYELADYVQLSEKYIVEILEHYKNKYGIGTHYGNYSITFEPLRVFKYSKI

Download         Length: 462 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12698.31 Da        Isoelectric Point: 6.2406

>AT273953 WP_243589040.1 NZ_CP119327:c1040903-1040574 [Staphylococcus sp. NRL 16/872]
MRNNDEIITIIKSAMKEQDMSLSELARRVGVAKSAVSRYLNLTREFPLNRSEDFAKALSISTEYLLGFDKSEQQHEQPLH
RAAHLEGELTDDEWQRVLDYADFIRSKRK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References