Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 878051..878580 Replicon chromosome
Accession NZ_CP119327
Organism Staphylococcus sp. NRL 16/872

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag MT340_RS04235 Protein ID WP_243588914.1
Coordinates 878218..878580 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag MT340_RS04230 Protein ID WP_243588913.1
Coordinates 878051..878221 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MT340_RS04205 (MT340_004205) 873869..874348 + 480 WP_243588909.1 PH domain-containing protein -
MT340_RS04210 (MT340_004210) 874341..875867 + 1527 WP_243588910.1 PH domain-containing protein -
MT340_RS04215 (MT340_004215) 875860..876354 + 495 WP_243603600.1 PH domain-containing protein -
MT340_RS04220 (MT340_004220) 876375..876734 + 360 WP_243588911.1 holo-ACP synthase -
MT340_RS04225 (MT340_004225) 876816..877964 + 1149 WP_243588912.1 alanine racemase -
MT340_RS04230 (MT340_004230) 878051..878221 + 171 WP_243588913.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MT340_RS04235 (MT340_004235) 878218..878580 + 363 WP_243588914.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MT340_RS04240 (MT340_004240) 878894..879895 + 1002 WP_243588915.1 PP2C family protein-serine/threonine phosphatase -
MT340_RS04245 (MT340_004245) 879987..880313 + 327 WP_243588916.1 anti-sigma factor antagonist -
MT340_RS04250 (MT340_004250) 880339..880791 + 453 WP_243590233.1 anti-sigma B factor RsbW -
MT340_RS04255 (MT340_004255) 880766..881536 + 771 WP_243588917.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13618.79 Da        Isoelectric Point: 9.6742

>T273951 WP_243588914.1 NZ_CP119327:878218-878580 [Staphylococcus sp. NRL 16/872]
MIKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKHKYRLDRDSVILLEQIR
TLDKKRLKEKLTYLSEEKMKEVDEALDISLGLHEVRPQKT

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6339.97 Da        Isoelectric Point: 4.0121

>AT273951 WP_243588913.1 NZ_CP119327:878051-878221 [Staphylococcus sp. NRL 16/872]
MLTFNQNRSHSLEQSLKEGYAQMADLNLSLATEAFPLECEACDCNESYITSNYKSE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References