273948

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4414231..4414894 Replicon chromosome
Accession NZ_CP119319
Organism MAG: Kluyvera intermedia isolate MAG 4159

Toxin (Protein)


Gene name cptA Uniprot ID A0A3S4EYA3
Locus tag P0Y47_RS20350 Protein ID WP_062773047.1
Coordinates 4414478..4414894 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A3S4FV25
Locus tag P0Y47_RS20345 Protein ID WP_062773044.1
Coordinates 4414231..4414497 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P0Y47_RS20320 (4409626) 4409626..4410360 - 735 WP_073971084.1 MurR/RpiR family transcriptional regulator -
P0Y47_RS20325 (4410406) 4410406..4410720 + 315 WP_062773034.1 N(4)-acetylcytidine aminohydrolase -
P0Y47_RS20330 (4410879) 4410879..4411541 + 663 WP_279216061.1 hemolysin III family protein -
P0Y47_RS20335 (4411787) 4411787..4412914 + 1128 WP_279216062.1 IS481 family transposase -
P0Y47_RS20340 (4413000) 4413000..4413983 - 984 WP_153742213.1 tRNA-modifying protein YgfZ -
P0Y47_RS20345 (4414231) 4414231..4414497 + 267 WP_062773044.1 FAD assembly factor SdhE Antitoxin
P0Y47_RS20350 (4414478) 4414478..4414894 + 417 WP_062773047.1 protein YgfX Toxin
P0Y47_RS20355 (4414891) 4414891..4415412 - 522 WP_153744004.1 flavodoxin FldB -
P0Y47_RS20360 (4415515) 4415515..4416411 + 897 WP_062773053.1 site-specific tyrosine recombinase XerD -
P0Y47_RS20365 (4416433) 4416433..4417146 + 714 WP_062773056.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
P0Y47_RS20370 (4417152) 4417152..4418885 + 1734 WP_062773059.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 16416.32 Da        Isoelectric Point: 11.6889

>T273948 WP_062773047.1 NZ_CP119319:4414478-4414894 [Kluyvera intermedia]
VVLWQSDLRVSWRSQWLSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSLVVFDCVRSQRRIHSHQGEIKLLMDSRLRWRNQ
EWDILGTPWMLSSGMMLRIRRCDGGRRQHLWLAADSMNAQEWRDLRRILLQQPAPGQH

Download         Length: 417 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10507.00 Da        Isoelectric Point: 5.6125

>AT273948 WP_062773044.1 NZ_CP119319:4414231-4414497 [Kluyvera intermedia]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDEDKTVFIRLLECDDPDLFNWLMNHGKPANADFQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S4EYA3

Antitoxin

Source ID Structure
AlphaFold DB A0A3S4FV25

References