273946

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2318661..2319279 Replicon chromosome
Accession NZ_CP119319
Organism MAG: Kluyvera intermedia isolate MAG 4159

Toxin (Protein)


Gene name Hha Uniprot ID A0A447MKF0
Locus tag P0Y47_RS10685 Protein ID WP_062773821.1
Coordinates 2319061..2319279 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag P0Y47_RS10680 Protein ID WP_153743488.1
Coordinates 2318661..2319035 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P0Y47_RS10670 (2313747) 2313747..2314943 + 1197 WP_279217154.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
P0Y47_RS10675 (2314966) 2314966..2318112 + 3147 WP_153743487.1 multidrug efflux RND transporter permease subunit AcrB -
P0Y47_RS10680 (2318661) 2318661..2319035 + 375 WP_153743488.1 Hha toxicity modulator TomB Antitoxin
P0Y47_RS10685 (2319061) 2319061..2319279 + 219 WP_062773821.1 HHA domain-containing protein Toxin
P0Y47_RS10690 (2319420) 2319420..2319974 + 555 WP_279217155.1 maltose O-acetyltransferase -
P0Y47_RS10695 (2320078) 2320078..2320548 + 471 WP_062774064.1 YlaC family protein -
P0Y47_RS10700 (2320523) 2320523..2321968 - 1446 WP_279217156.1 PLP-dependent aminotransferase family protein -
P0Y47_RS10705 (2322071) 2322071..2322781 + 711 WP_279217157.1 GNAT family protein -
P0Y47_RS10710 (2322778) 2322778..2322918 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
P0Y47_RS10715 (2322918) 2322918..2323181 - 264 WP_052283831.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8624.01 Da        Isoelectric Point: 8.9008

>T273946 WP_062773821.1 NZ_CP119319:2319061-2319279 [Kluyvera intermedia]
MSDKPLTKTDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPPTVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14325.07 Da        Isoelectric Point: 4.8887

>AT273946 WP_153743488.1 NZ_CP119319:2318661-2319035 [Kluyvera intermedia]
MDEYSPKRHDIAQLKFLCETLYHDSLATLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYSEDNKLIAQIDEYL
DDTFMLFGNYGINSDDLQKWRKSGNKLFRCFVNASRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A447MKF0

Antitoxin

Source ID Structure

References