Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2357420..2358398 Replicon chromosome
Accession NZ_CP119300
Organism Bacillus cereus strain M72-4

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag PZ893_RS12225 Protein ID WP_000624975.1
Coordinates 2357420..2358157 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID W8YZL5
Locus tag PZ893_RS12230 Protein ID WP_000237818.1
Coordinates 2358270..2358398 (+) Length 43 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PZ893_RS12205 (PZ893_12205) 2353149..2353844 + 696 WP_224742171.1 class I SAM-dependent methyltransferase -
PZ893_RS12210 (PZ893_12210) 2354002..2355678 - 1677 WP_139256968.1 alpha-keto acid decarboxylase family protein -
PZ893_RS12215 (PZ893_12215) 2355795..2356277 + 483 WP_072770281.1 MarR family winged helix-turn-helix transcriptional regulator -
PZ893_RS12220 (PZ893_12220) 2356444..2357181 + 738 WP_000594152.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
PZ893_RS12225 (PZ893_12225) 2357420..2358157 + 738 WP_000624975.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
PZ893_RS12230 (PZ893_12230) 2358270..2358398 + 129 WP_000237818.1 hypothetical protein Antitoxin
PZ893_RS12235 (PZ893_12235) 2358471..2358647 + 177 WP_065382523.1 stage II sporulation protein SB -
PZ893_RS12240 (PZ893_12240) 2358667..2359056 - 390 WP_000713862.1 YxeA family protein -
PZ893_RS12245 (PZ893_12245) 2359268..2360737 + 1470 WP_065382524.1 beta-Ala-His dipeptidase -
PZ893_RS12250 (PZ893_12250) 2360983..2361792 + 810 WP_065382626.1 papain-like cysteine protease family protein -
PZ893_RS12255 (PZ893_12255) 2361818..2362420 + 603 WP_065382625.1 hypothetical protein -
PZ893_RS12260 (PZ893_12260) 2362663..2362914 - 252 WP_000827560.1 LuxR C-terminal-related transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(10-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28278.98 Da        Isoelectric Point: 8.2998

>T273940 WP_000624975.1 NZ_CP119300:2357420-2358157 [Bacillus cereus]
MISNIRIGLFVLAIVFVVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMAIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

Antitoxin


Download         Length: 43 a.a.        Molecular weight: 5011.40 Da        Isoelectric Point: 3.9150

>AT273940 WP_000237818.1 NZ_CP119300:2358270-2358398 [Bacillus cereus]
VVKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRKS

Download         Length: 129 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB W8YZL5

References