Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 252884..253526 Replicon chromosome
Accession NZ_CP119300
Organism Bacillus cereus strain M72-4

Toxin (Protein)


Gene name pemK Uniprot ID J8CWW5
Locus tag PZ893_RS01415 Protein ID WP_000635963.1
Coordinates 253176..253526 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag PZ893_RS01410 Protein ID WP_000004570.1
Coordinates 252884..253171 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PZ893_RS01385 (PZ893_01385) 248201..249163 + 963 WP_000961165.1 UV DNA damage repair endonuclease UvsE -
PZ893_RS01390 (PZ893_01390) 249156..249728 - 573 WP_000908523.1 rhomboid family intramembrane serine protease -
PZ893_RS01395 (PZ893_01395) 249822..250181 + 360 WP_000583416.1 holo-ACP synthase -
PZ893_RS01400 (PZ893_01400) 250338..251288 + 951 WP_002004297.1 outer membrane lipoprotein carrier protein LolA -
PZ893_RS01405 (PZ893_01405) 251406..252575 + 1170 WP_000390615.1 alanine racemase -
PZ893_RS01410 (PZ893_01410) 252884..253171 + 288 WP_000004570.1 antitoxin EndoAI Antitoxin
PZ893_RS01415 (PZ893_01415) 253176..253526 + 351 WP_000635963.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
PZ893_RS01420 (PZ893_01420) 253594..255762 + 2169 WP_000426242.1 Tex family protein -
PZ893_RS01425 (PZ893_01425) 255820..255936 - 117 WP_001143642.1 cortex morphogenetic protein CmpA -
PZ893_RS01430 (PZ893_01430) 256132..256590 + 459 WP_000344234.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12974.12 Da        Isoelectric Point: 5.7168

>T273939 WP_000635963.1 NZ_CP119300:253176-253526 [Bacillus cereus]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMIRVDEALQISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT273939 WP_000004570.1 NZ_CP119300:252884-253171 [Bacillus cereus]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4HKE
PDB 7BXY

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References