273934

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 165493..165998 Replicon chromosome
Accession NZ_CP119298
Organism Pseudomonas aeruginosa strain SNDPR-01

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag PZ484_RS00770 Protein ID WP_003121619.1
Coordinates 165493..165774 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag PZ484_RS00775 Protein ID WP_003112628.1
Coordinates 165771..165998 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PZ484_RS00745 160744..162093 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
PZ484_RS00750 162142..162828 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
PZ484_RS00755 162929..163663 + 735 WP_003117208.1 GntR family transcriptional regulator -
PZ484_RS00760 163843..164253 + 411 WP_003101225.1 aegerolysin family protein -
PZ484_RS00765 164285..165193 - 909 WP_016561475.1 LysR family transcriptional regulator -
PZ484_RS00770 165493..165774 - 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
PZ484_RS00775 165771..165998 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
PZ484_RS00780 166174..166794 - 621 WP_003101226.1 hypothetical protein -
PZ484_RS00785 166895..167395 + 501 WP_003112629.1 LEA type 2 family protein -
PZ484_RS00790 167468..167809 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
PZ484_RS00795 167891..169318 - 1428 WP_003083784.1 GABA permease -
PZ484_RS00800 169487..170980 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T273934 WP_003121619.1 NZ_CP119298:c165774-165493 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT273934 WP_003112628.1 NZ_CP119298:c165998-165771 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
AlphaFold DB Q9I707

References