273933

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 3997355..3998926 Replicon chromosome
Accession NZ_CP119297
Organism Proteus mirabilis strain HK294

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag P1A26_RS18475 Protein ID WP_063073818.1
Coordinates 3997355..3998668 (-) Length 438 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag P1A26_RS18480 Protein ID WP_049203075.1
Coordinates 3998669..3998926 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1A26_RS18450 (P1A26_18450) 3992524..3992664 + 141 WP_275621966.1 hypothetical protein -
P1A26_RS18455 (P1A26_18455) 3992692..3993327 + 636 WP_275621990.1 energy transducer TonB -
P1A26_RS18460 (P1A26_18460) 3993381..3995342 - 1962 WP_063073816.1 insecticidal delta-endotoxin Cry8Ea1 family protein -
P1A26_RS18465 (P1A26_18465) 3995374..3996303 - 930 WP_004246518.1 metallophosphoesterase -
P1A26_RS18470 (P1A26_18470) 3996488..3996952 - 465 WP_063073817.1 DUF1097 domain-containing protein -
P1A26_RS18475 (P1A26_18475) 3997355..3998668 - 1314 WP_063073818.1 type II toxin-antitoxin system HipA family toxin Toxin
P1A26_RS18480 (P1A26_18480) 3998669..3998926 - 258 WP_049203075.1 helix-turn-helix domain-containing protein Antitoxin
P1A26_RS18485 (P1A26_18485) 3999075..4000439 - 1365 WP_004246513.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
P1A26_RS18490 (P1A26_18490) 4000577..4002217 - 1641 WP_004246512.1 membrane protein insertase YidC -
P1A26_RS18495 (P1A26_18495) 4002220..4002480 - 261 WP_012368639.1 membrane protein insertion efficiency factor YidD -
P1A26_RS18500 (P1A26_18500) 4002444..4002803 - 360 WP_004246510.1 ribonuclease P protein component -
P1A26_RS18505 (P1A26_18505) 4002821..4002964 - 144 WP_004246509.1 50S ribosomal protein L34 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 438 a.a.        Molecular weight: 49674.86 Da        Isoelectric Point: 6.7643

>T273933 WP_063073818.1 NZ_CP119297:c3998668-3997355 [Proteus mirabilis]
MASLDVYMNEYYVGIFTKKSSGAHSFQYTEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNTEIRNRIVSRYN
ANSNQPFDLLVAIGADTVGALRLLPSGSTPANIKKIEYQKLNDIELEKILLGYKSNTPLGMLKKYTDFRISIAGAQEKTA
LLLKDNDWCVPHNNTPTTHIIKLPIGVIESHSYTMDLSNSVENEYLCTLIAKEFDLPVPHCSIIKTKNVKALAVERFDRK
YSSDKSWIIRLPQEDFCQILNIPSALKYENEGGPGIIDIMKYLLGSSNADQDRFHFMKAQVLFWLLAATDGHAKNFSVFI
NQEGRFHLTPLYDIMSIYPNFGGRGLNPRDAKLAMGLKASRGKKYAIEQIFPRHFYQTAEAVGFDPSLMSDILRYFYQEM
DDVIQRVKQQLPEDFPSEISNTILDGMKARAVRLANI

Download         Length: 1314 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9878.43 Da        Isoelectric Point: 10.0139

>AT273933 WP_049203075.1 NZ_CP119297:c3998926-3998669 [Proteus mirabilis]
MIIINAYQLSVHLKDVRLTKKLSQSKVAQKVGIRQDTVSNFEINPNSTKLETFFKLLSALNLEMEIHPKDAKNNLAHKSE
WKEEW

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References