Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-MqsA
Location 3657184..3657883 Replicon chromosome
Accession NZ_CP119297
Organism Proteus mirabilis strain HK294

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag P1A26_RS16950 Protein ID WP_017628658.1
Coordinates 3657184..3657570 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B4EZ97
Locus tag P1A26_RS16955 Protein ID WP_004246828.1
Coordinates 3657563..3657883 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1A26_RS16935 (P1A26_16935) 3653203..3653784 - 582 WP_012368524.1 DNA-3-methyladenine glycosylase I -
P1A26_RS16940 (P1A26_16940) 3654035..3654940 + 906 WP_004246832.1 glycine--tRNA ligase subunit alpha -
P1A26_RS16945 (P1A26_16945) 3654950..3657022 + 2073 WP_017628659.1 glycine--tRNA ligase subunit beta -
P1A26_RS16950 (P1A26_16950) 3657184..3657570 + 387 WP_017628658.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P1A26_RS16955 (P1A26_16955) 3657563..3657883 + 321 WP_004246828.1 helix-turn-helix domain-containing protein Antitoxin
P1A26_RS16960 (P1A26_16960) 3657932..3658366 - 435 WP_004246827.1 hypothetical protein -
P1A26_RS16965 (P1A26_16965) 3658359..3659243 - 885 WP_012368526.1 endonuclease/exonuclease/phosphatase family protein -
P1A26_RS16970 (P1A26_16970) 3659458..3660744 - 1287 WP_063073863.1 DUF3748 domain-containing protein -
P1A26_RS16975 (P1A26_16975) 3660881..3661498 + 618 WP_004246822.1 trimeric intracellular cation channel family protein -
P1A26_RS16980 (P1A26_16980) 3661799..3662422 + 624 WP_004246821.1 guanylate kinase -
P1A26_RS16985 (P1A26_16985) 3662477..3662752 + 276 WP_004246820.1 DNA-directed RNA polymerase subunit omega -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-125)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-95)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14322.65 Da        Isoelectric Point: 10.0826

>T273932 WP_017628658.1 NZ_CP119297:3657184-3657570 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVRYD

Download         Length: 387 bp

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12126.21 Da        Isoelectric Point: 10.4411

>AT273932 WP_004246828.1 NZ_CP119297:3657563-3657883 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Download         Length: 321 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB B4EZ97

References