Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
| Location | 3281981..3283703 | Replicon | chromosome |
| Accession | NZ_CP119297 | ||
| Organism | Proteus mirabilis strain HK294 | ||
Toxin (Protein)
| Gene name | mosT | Uniprot ID | B4EWT0 |
| Locus tag | P1A26_RS15330 | Protein ID | WP_012368380.1 |
| Coordinates | 3281981..3282919 (-) | Length | 313 a.a. |
Antitoxin (Protein)
| Gene name | mosA | Uniprot ID | - |
| Locus tag | P1A26_RS15335 | Protein ID | WP_041707152.1 |
| Coordinates | 3282912..3283703 (-) | Length | 264 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| P1A26_RS15310 (P1A26_15310) | 3277922..3278434 | - | 513 | WP_175215521.1 | S26 family signal peptidase | - |
| P1A26_RS15315 (P1A26_15315) | 3278418..3278765 | - | 348 | WP_064497038.1 | hypothetical protein | - |
| P1A26_RS15320 (P1A26_15320) | 3278758..3281157 | - | 2400 | WP_064497039.1 | type IV secretion system protein TraC | - |
| P1A26_RS15325 (P1A26_15325) | 3281157..3281849 | - | 693 | WP_001228924.1 | DsbC family protein | - |
| P1A26_RS15330 (P1A26_15330) | 3281981..3282919 | - | 939 | WP_012368380.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| P1A26_RS15335 (P1A26_15335) | 3282912..3283703 | - | 792 | WP_041707152.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| P1A26_RS15340 (P1A26_15340) | 3283923..3284309 | - | 387 | WP_000180225.1 | TraA family conjugative transfer protein | - |
| P1A26_RS15345 (P1A26_15345) | 3284306..3284878 | - | 573 | WP_001944091.1 | type IV conjugative transfer system lipoprotein TraV | - |
| P1A26_RS15350 (P1A26_15350) | 3284953..3286242 | - | 1290 | WP_012368382.1 | TraB/VirB10 family protein | - |
| P1A26_RS15355 (P1A26_15355) | 3286245..3287141 | - | 897 | WP_041707153.1 | type-F conjugative transfer system secretin TraK | - |
| P1A26_RS15360 (P1A26_15360) | 3287125..3287751 | - | 627 | WP_000667170.1 | TraE/TraK family type IV conjugative transfer system protein | - |
| P1A26_RS15365 (P1A26_15365) | 3287748..3288029 | - | 282 | WP_000433891.1 | type IV conjugative transfer system protein TraL | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | tet(J) / aadA2 / ere(A) / dfrA32 / sul1 / qacE / ARR-3 / catB3 / blaOXA-1 / aac(6')-Ib-cr / aac(3)-IVa / aph(4)-Ia / sul2 / blaCTX-M-65 / fosA3 / aph(3')-Ia / tet(C) | - | 3141029..3359394 | 218365 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 313 a.a. Molecular weight: 35534.79 Da Isoelectric Point: 4.9081
>T273931 WP_012368380.1 NZ_CP119297:c3282919-3281981 [Proteus mirabilis]
MDKDSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALVNVRAALQRITDRINTQ
PDIRAAFQDNKADELRIVVSSPVATIKIEVSPVARGTLHSAEIMPVQESVEDEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGISREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLIELQK
HFTERDHAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLVNANAE
MDKDSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALVNVRAALQRITDRINTQ
PDIRAAFQDNKADELRIVVSSPVATIKIEVSPVARGTLHSAEIMPVQESVEDEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGISREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLIELQK
HFTERDHAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLVNANAE
Download Length: 939 bp
Antitoxin
Download Length: 264 a.a. Molecular weight: 30116.50 Da Isoelectric Point: 9.3718
>AT273931 WP_041707152.1 NZ_CP119297:c3283703-3282912 [Proteus mirabilis]
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLCSGVYYRPDARGDIKPTWVDAIQALDVQLGVSVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDGIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRVDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLCSGVYYRPDARGDIKPTWVDAIQALDVQLGVSVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDGIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRVDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG
Download Length: 792 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|