Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1722801..1723600 Replicon chromosome
Accession NZ_CP119297
Organism Proteus mirabilis strain HK294

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A8E3RD10
Locus tag P1A26_RS08295 Protein ID WP_004247966.1
Coordinates 1723076..1723600 (+) Length 175 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID B4EVS2
Locus tag P1A26_RS08290 Protein ID WP_004247964.1
Coordinates 1722801..1723079 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1A26_RS08265 (P1A26_08265) 1718151..1719233 + 1083 WP_004242680.1 peptide chain release factor 1 -
P1A26_RS08270 (P1A26_08270) 1719233..1720081 + 849 WP_004247962.1 peptide chain release factor N(5)-glutamine methyltransferase -
P1A26_RS08275 (P1A26_08275) 1720059..1720874 + 816 WP_004242688.1 invasion regulator SirB1 -
P1A26_RS08280 (P1A26_08280) 1720932..1721786 + 855 WP_004242689.1 3-deoxy-8-phosphooctulonate synthase -
P1A26_RS08285 (P1A26_08285) 1721794..1722723 + 930 WP_017628160.1 TIGR01212 family radical SAM protein -
P1A26_RS08290 (P1A26_08290) 1722801..1723079 + 279 WP_004247964.1 DUF1778 domain-containing protein Antitoxin
P1A26_RS08295 (P1A26_08295) 1723076..1723600 + 525 WP_004247966.1 hypothetical protein Toxin
P1A26_RS08300 (P1A26_08300) 1723681..1725381 - 1701 WP_017628159.1 C4-dicarboxylic acid transporter DauA -
P1A26_RS08310 (P1A26_08310) 1726345..1727286 + 942 WP_275621986.1 glyoxylate/hydroxypyruvate reductase GhrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(5-87)


Sequences

Toxin        


Download         Length: 175 a.a.        Molecular weight: 19192.12 Da        Isoelectric Point: 9.3561

>T273929 WP_004247966.1 NZ_CP119297:1723076-1723600 [Proteus mirabilis]
MTIPNWHEEAISKKHNRNGFNCGDAVLNQFLYRHARQNHENGSAKTYLAINNSNNIILGYYSLCPASIEFERTPELIKHG
LARHDIPVFKLARLATDLSVQGKGLGGQLLLAAGRRCLSVASELGGVALLIDAKNERVANWYISYGAIPLLDTPLSLLIS
FKTIYTALSMANKI

Download         Length: 525 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10252.82 Da        Isoelectric Point: 5.1369

>AT273929 WP_004247964.1 NZ_CP119297:1722801-1723079 [Proteus mirabilis]
MAQALVENSERVSIRITTEDKSLLVRAASLENTNLTEFVLRNIVPVARQVIENNERLKLSEKDTLRVMELLDNPPKPNAK
LLAAAFALPDNA

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB B4EVS2

References