Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 78682..79210 Replicon plasmid pAP54-2
Accession NZ_CP119225
Organism Acinetobacter proteolyticus strain AP54

Toxin (Protein)


Gene name relE Uniprot ID N9N871
Locus tag PY247_RS23410 Protein ID WP_000221358.1
Coordinates 78682..78975 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID N9NWT9
Locus tag PY247_RS23415 Protein ID WP_000246755.1
Coordinates 78965..79210 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PY247_RS23395 (PY247_23395) 75755..76981 + 1227 WP_004781038.1 putative acinetoferrin export transporter ActD -
PY247_RS23400 (PY247_23400) 77092..78024 + 933 WP_275574305.1 IS5 family transposase -
PY247_RS23405 (PY247_23405) 78224..78553 + 330 WP_004827037.1 four-helix bundle copper-binding protein -
PY247_RS23410 (PY247_23410) 78682..78975 - 294 WP_000221358.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PY247_RS23415 (PY247_23415) 78965..79210 - 246 WP_000246755.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PY247_RS23420 (PY247_23420) 79312..79683 - 372 WP_004726814.1 hypothetical protein -
PY247_RS23425 (PY247_23425) 79908..80105 - 198 WP_004726812.1 hypothetical protein -
PY247_RS23430 (PY247_23430) 80185..81117 - 933 WP_004726810.1 IS5 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..107216 107216
- inside IScluster/Tn - - 77155..94107 16952


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-84)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11292.52 Da        Isoelectric Point: 10.4753

>T273925 WP_000221358.1 NZ_CP119225:c78975-78682 [Acinetobacter proteolyticus]
MTYKLLRHKDFTAEWEKLPVAIRDQFKKKLAKVIEQPHIPKNMLRGDLAGCYKIKLLKAGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKD

Download         Length: 294 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9249.64 Da        Isoelectric Point: 4.3142

>AT273925 WP_000246755.1 NZ_CP119225:c79210-78965 [Acinetobacter proteolyticus]
MATVNFRIDEALKEKSYSILKEQGIAPTDFFTSILEYVATTGKLPVKKALLSEEDEELLALVRKRINDPKEMFEEVTLDD
L

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6A1RKP4

Antitoxin

Source ID Structure
AlphaFold DB A0A6A1RJ80

References