Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | BrnTA/BrnT-BrnA |
Location | 146574..147162 | Replicon | plasmid pAP54-1 |
Accession | NZ_CP119224 | ||
Organism | Acinetobacter proteolyticus strain AP54 |
Toxin (Protein)
Gene name | brnT | Uniprot ID | N8SM64 |
Locus tag | PY247_RS22390 | Protein ID | WP_000438825.1 |
Coordinates | 146875..147162 (-) | Length | 96 a.a. |
Antitoxin (Protein)
Gene name | brnA | Uniprot ID | D3JXQ4 |
Locus tag | PY247_RS22385 | Protein ID | WP_004728120.1 |
Coordinates | 146574..146888 (-) | Length | 105 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
PY247_RS22350 (PY247_22350) | 142033..143508 | - | 1476 | WP_000052512.1 | ABC-F type ribosomal protection protein Msr(E) | - |
PY247_RS22355 (PY247_22355) | 143999..144271 | - | 273 | WP_000369781.1 | NadS family protein | - |
PY247_RS22360 (PY247_22360) | 144264..144584 | - | 321 | WP_000897307.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
PY247_RS22365 (PY247_22365) | 144724..145143 | + | 420 | WP_001180106.1 | SMI1/KNR4 family protein | - |
PY247_RS22370 (PY247_22370) | 145222..145503 | - | 282 | WP_000985609.1 | putative addiction module antidote protein | - |
PY247_RS22375 (PY247_22375) | 145504..145806 | - | 303 | WP_275574235.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
PY247_RS22380 (PY247_22380) | 145955..146485 | + | 531 | WP_000172759.1 | hypothetical protein | - |
PY247_RS22385 (PY247_22385) | 146574..146888 | - | 315 | WP_004728120.1 | BrnA antitoxin family protein | Antitoxin |
PY247_RS22390 (PY247_22390) | 146875..147162 | - | 288 | WP_000438825.1 | BrnT family toxin | Toxin |
PY247_RS22395 (PY247_22395) | 147403..148173 | - | 771 | WP_032073134.1 | hypothetical protein | - |
PY247_RS22400 (PY247_22400) | 148232..148570 | + | 339 | WP_032073153.1 | hypothetical protein | - |
PY247_RS22405 (PY247_22405) | 148698..149402 | - | 705 | WP_001067784.1 | IS6-like element IS1006 family transposase | - |
PY247_RS22410 (PY247_22410) | 149466..150298 | + | 833 | Protein_147 | IS91-like element ISVsa3 family transposase | - |
PY247_RS22415 (PY247_22415) | 150534..150776 | - | 243 | Protein_148 | phosphoglucosamine mutase | - |
PY247_RS22420 (PY247_22420) | 150863..151676 | - | 814 | Protein_149 | sulfonamide-resistant dihydropteroate synthase Sul2 | - |
PY247_RS22425 (PY247_22425) | 151766..151999 | + | 234 | Protein_150 | IS4 family transposase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | sul1 / qacE / aadA5 / aac(6')-IIa / blaIMP-1 / floR / mph(E) / msr(E) / sul2 / blaOXA-58 / dfrA1 / aph(3')-VIa | - | 1..248123 | 248123 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11304.70 Da Isoelectric Point: 5.6205
>T273924 WP_000438825.1 NZ_CP119224:c147162-146875 [Acinetobacter proteolyticus]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTDGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTDGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG
Download Length: 288 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0A8TVQ4 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0A8TRI9 |