Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 145222..145806 Replicon plasmid pAP54-1
Accession NZ_CP119224
Organism Acinetobacter proteolyticus strain AP54

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag PY247_RS22375 Protein ID WP_275574235.1
Coordinates 145504..145806 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag PY247_RS22370 Protein ID WP_000985609.1
Coordinates 145222..145503 (-) Length 94 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PY247_RS22345 (PY247_22345) 141093..141977 - 885 WP_000155092.1 Mph(E) family macrolide 2'-phosphotransferase -
PY247_RS22350 (PY247_22350) 142033..143508 - 1476 WP_000052512.1 ABC-F type ribosomal protection protein Msr(E) -
PY247_RS22355 (PY247_22355) 143999..144271 - 273 WP_000369781.1 NadS family protein -
PY247_RS22360 (PY247_22360) 144264..144584 - 321 WP_000897307.1 type II toxin-antitoxin system RelE/ParE family toxin -
PY247_RS22365 (PY247_22365) 144724..145143 + 420 WP_001180106.1 SMI1/KNR4 family protein -
PY247_RS22370 (PY247_22370) 145222..145503 - 282 WP_000985609.1 putative addiction module antidote protein Antitoxin
PY247_RS22375 (PY247_22375) 145504..145806 - 303 WP_275574235.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PY247_RS22380 (PY247_22380) 145955..146485 + 531 WP_000172759.1 hypothetical protein -
PY247_RS22385 (PY247_22385) 146574..146888 - 315 WP_004728120.1 BrnA antitoxin family protein -
PY247_RS22390 (PY247_22390) 146875..147162 - 288 WP_000438825.1 BrnT family toxin -
PY247_RS22395 (PY247_22395) 147403..148173 - 771 WP_032073134.1 hypothetical protein -
PY247_RS22400 (PY247_22400) 148232..148570 + 339 WP_032073153.1 hypothetical protein -
PY247_RS22405 (PY247_22405) 148698..149402 - 705 WP_001067784.1 IS6-like element IS1006 family transposase -
PY247_RS22410 (PY247_22410) 149466..150298 + 833 Protein_147 IS91-like element ISVsa3 family transposase -
PY247_RS22415 (PY247_22415) 150534..150776 - 243 Protein_148 phosphoglucosamine mutase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid sul1 / qacE / aadA5 / aac(6')-IIa / blaIMP-1 / floR / mph(E) / msr(E) / sul2 / blaOXA-58 / dfrA1 / aph(3')-VIa - 1..248123 248123


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(12-90)

Antitoxin

(4-91)


Sequences


Toxin        


Download         Length: 101 a.a.        Molecular weight: 11603.14 Da        Isoelectric Point: 4.6838

>T273923 WP_275574235.1 NZ_CP119224:c145806-145504 [Acinetobacter proteolyticus]
MYSIYTTEVFDDWFTKLKDQQAKRRIQVRIDRVEDGNFGDTELIGEGVSELRFFFGPGYRIYYCKQGQRVVILLAGGDKS
TQSKDIKLALQLAQDLEEEL

Download         Length: 303 bp


Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10109.67 Da        Isoelectric Point: 8.0018

>AT273923 WP_000985609.1 NZ_CP119224:c145503-145222 [Acinetobacter proteolyticus]
MAIKLRKWDSAEHLKTEDDMQAYLQACIEESNGDAAFIAKALGNIAKAKGMAQLSRDTGLGRESLYKALSGDVNPSFDTV
IKVVKALNLRLAI

Download         Length: 282 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References